Rabbit anti-Human, Mouse ELAVL3 Polyclonal Antibody | anti-ELAVL3 antibody

ELAVL3 Antibody

Cat. Num. AAA9410656

• Gene Names: ELAVL3; HUC; HUCL; PLE21
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: ELAVL3; Polyclonal Antibody; ELAVL3 Antibody; HUC; HUCL; PLE21; anti-ELAVL3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ELAVL3 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.3 mg/ml (varies by lot)
• Sequence Length: 367

• Applicable Applications for anti-ELAVL3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:200-1:1000; Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the N terminal of human ELAV like neuron-specific RNA binding protein 3
• Target Name: ELAVL3
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 10%SDS-PAGE Lysates (from left to right): Human fetal brain tissue Amount of lysate: 40ug per lane Primary antibody: 1/350 dilution Secondary antibody dilution: 1/8000 Exposure time: 3 minutes)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/20.)

Related Product Information for anti-ELAVL3 antibody

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Product Categories/Family for anti-ELAVL3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 49355761
• NCBI GeneID: 1995
• NCBI Accession #: NP_001411.2
• NCBI GenBank Nucleotide #: NM_001420.3
• UniProt Accession #: Q14576; Q16135; Q96CL8; Q96QS9
• Molecular Weight: 38,865 Da
• NCBI Official Full Name: ELAV-like protein 3 isoform 1
• NCBI Official Synonym Full Names: ELAV like neuron-specific RNA binding protein 3
• NCBI Official Symbol: ELAVL3
• NCBI Official Synonym Symbols: HUC; HUCL; PLE21
• NCBI Protein Information: ELAV-like protein 3
• UniProt Protein Name: ELAV-like protein 3
• Protein Family: ELAV-like protein
• UniProt Gene Name: ELAVL3
• UniProt Synonym Gene Names: HUC; PLE21; HuC
• UniProt Entry Name: ELAV3_HUMAN

NCBI Description

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ELAVL3: Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19p13.2

Molecular Function: nucleotide binding; AU-rich element binding

Biological Process: nervous system development; cell differentiation