Rabbit anti-Mouse E2f6 Polyclonal Antibody | anti-E2f6 antibody

Anti-E2f6 Antibody, Rabbit Polyclonal

Cat. Num. AAA8103359

• Gene Names: E2f6; EMA; E2F6b; AI462434
• Reactivity: Mouse
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: E2f6; Polyclonal Antibody; Anti-E2f6 Antibody; Rabbit Polyclonal; E2F6 Antibody; Rabbit PAb; Antigen Affinity Purified; anti-E2f6 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse E2F6
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-E2f6 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Mouse E2F6
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse E2F6, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of mouse E2F6 in mouse brain with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-E2f6 antibody

The E2f6 transcriptional repressor is an E2F-family member essential for the silencing of a group of meiosis-specific genes in somatic tissues. E2f6 has been shown to associate with both polycomb repressive complexes (PRC) and the methyltransferase Dnmt3b. E2F transcription factors play an important role in regulating mammalian cell proliferation. E2F6, the most recently identified E2F family member, is a transcriptional repressor.

NCBI and Uniprot Product Information

• NCBI GI #: 237681138
• NCBI GeneID: 50496
• NCBI Accession #: NP_150373.2
• NCBI GenBank Nucleotide #: NM_033270.2
• UniProt Accession #: O54917; Q8K456
• Molecular Weight: 30,852 Da
• NCBI Official Full Name: transcription factor E2F6
• NCBI Official Synonym Full Names: E2F transcription factor 6
• NCBI Official Symbol: E2f6
• NCBI Official Synonym Symbols: EMA; E2F6b; AI462434
• NCBI Protein Information: transcription factor E2F6; E2F-6; transcriptional repressor E2F6; E2F-binding site-modulating activity protein
• UniProt Protein Name: Transcription factor E2F6
• Protein Family: Transcription factor
• UniProt Gene Name: E2f6
• UniProt Synonym Gene Names: E2F-6; EMA
• UniProt Entry Name: E2F6_MOUSE

Uniprot Description

E2F6: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase. Belongs to the E2F/DP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Cellular Component: transcription factor complex; DNA replication factor A complex; nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent; cell cycle