Rabbit anti-Human ARID3A Polyclonal Antibody | anti-ARID3A antibody

Anti-ARID3A Antibody, Rabbit Polyclonal

Cat. Num. AAA8101360

• Gene Names: ARID3A; DRIL1; DRIL3; BRIGHT; E2FBP1
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: ARID3A; Polyclonal Antibody; Anti-ARID3A Antibody; Rabbit Polyclonal; ARID3A Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-BRIGHT Antibody; Anti-DRIL1 Antibody; Anti-DRIL3 Antibody; Anti-E2FBP1 Antibody; anti-ARID3A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human ARID3A
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-ARID3A antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Human ARID3A
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human ARID3A, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human ARID1A in human ovarian cancer with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Immunohistochemistry (IHC)

(Immunochemical staining of human ARID1A in human colon carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-ARID3A antibody

ARID3A/DRIL1/Bright is a family member of the AT rich interaction domain (ARID) DNA-binding proteins that are involved in diverse biological processes, and p53 activates ARID3A transcription, and ARID3A overexpression induces G1 arrest. Both cooperative and interdependent roles for ARID3A and p53 in the transcriptional activation of p21(WAF1) in response to DNA damage. Conventional Arid3a knockout embryos suffer restricted intrauterine growth with severe defects in placental structural organization. ARID3A in mammalian placental development through regulation of both intrinsic and extrinsic developmental programs. AT-rich interactive domain 3A (ARID3A) is a member of the ARID family of DNA-binding proteins. Previous reports have shown that ARID3A controls cell growth in a p53-dependent manner. Recently, it has been reported that expression of the ARID3A protein was markedly increased in colon cancer tissue compared with matched normal colonic mucosa. ARID3A plays an important role in E2F-mediated transcriptional activation and cell growth. Bright/ARID3A is a nuclear matrix-associated transcription factor that stimulates immunoglobulin heavy chain (IgH) expression and Cyclin E1/E2F-dependent cell cycle progression. Bright positively activates IgH transcriptional initiation by binding to ATC-rich P sites within nuclear matrix attachment regions (MARs) flanking the IgH intronic enhancer (Emu).

NCBI and Uniprot Product Information

• NCBI GI #: 12230034
• NCBI GeneID: 1820
• UniProt Accession #: Q99856; Q5I858; Q6P9C6; Q8IZA7; Q8N4Z3
• Molecular Weight: 593
• NCBI Official Full Name: AT-rich interactive domain-containing protein 3A
• NCBI Official Synonym Full Names: AT rich interactive domain 3A (BRIGHT-like)
• NCBI Official Symbol: ARID3A
• NCBI Official Synonym Symbols: DRIL1; DRIL3; BRIGHT; E2FBP1
• NCBI Protein Information: AT-rich interactive domain-containing protein 3A; dead ringer-like 1; E2F-binding protein 1; ARID domain-containing 3A; dead ringer-like protein 1; ARID domain-containing protein 3A; B-cell regulator of IgH transcription; AT rich interactive domain 3A (BR
• UniProt Protein Name: AT-rich interactive domain-containing protein 3A
• Protein Family: AT-rich interactive domain-containing protein
• UniProt Gene Name: ARID3A
• UniProt Synonym Gene Names: DRIL1; DRIL3; DRX; E2FBP1; ARID domain-containing protein 3A; Bright
• UniProt Entry Name: ARI3A_HUMAN

NCBI Description

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

Uniprot Description

Bright: a member of the ARID (AT-rich interaction domain) family of transcription factors. It was found by its homology to the Drosophila dead ringer protein, which is important for normal embryogenesis. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. Contributes to localized control of accessibility and therefore nonrandom gene use during V(D)J recombination.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleolus; lipid raft

Molecular Function: protein binding; protein homodimerization activity; chromatin binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter