Rabbit anti-Rat E-Cadherin Polyclonal Antibody | anti-CDH1 antibody
Anti-E-Cadherin Antibody, Rabbit Polyclonal
NCBI and Uniprot Product Information
NCBI Description
cell-cell adhesion molecule; may play a role in axonal growth and synase formation [RGD, Feb 2006]
Uniprot Description
CDH1: a single-pass type I membrane protein, and calcium dependent cell adhesion proteins. It is a ligand for integrin alpha-E/beta-7, and it colocalizes with DLG7 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis. Has a potent invasive suppressor role.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Ubiquitin ligase; Membrane protein, integral
Cellular Component: actin cytoskeleton; adherens junction; apical junction complex; apical part of cell; axon; basolateral plasma membrane; catenin complex; cell junction; cell surface; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasm; endosome; flotillin complex; focal adhesion; integral to membrane; intercellular junction; internal side of plasma membrane; lamellipodium; lateral loop; lateral plasma membrane; nerve terminal; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network
Molecular Function: ankyrin binding; beta-catenin binding; calcium ion binding; cell adhesion molecule binding; gamma-catenin binding; glycoprotein binding; GTPase activating protein binding; protein binding; protein domain specific binding; protein phosphatase binding
Biological Process: calcium-dependent cell-cell adhesion; cell-cell adhesion; decidualization; embryo implantation; homophilic cell adhesion; in utero embryonic development; negative regulation of cell-cell adhesion; negative regulation of epithelial cell proliferation; neurite development; pituitary gland development; positive regulation of transcription factor import into nucleus; positive regulation of transcription, DNA-dependent; protein homooligomerization; protein metabolic process; regulation of caspase activity; regulation of protein localization; regulation of water loss via skin; response to drug; response to organic substance; response to toxin; sensory perception of sound; synaptogenesis; trophectodermal cell differentiation
Research Articles on CDH1
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Product Notes
The CDH1 cdh1 (Catalog #AAA8112887) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-E-Cadherin Antibody, Rabbit Polyclonal reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's E-Cadherin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:1000-1:2000. Researchers should empirically determine the suitability of the CDH1 cdh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "E-Cadherin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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