Rabbit DUSP9 Polyclonal Antibody | anti-DUSP9 antibody

DUSP9 Rabbit Polyclonal

Cat. Num. AAA768803

• Gene Names: DUSP9; MKP4; MKP-4
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: DUSP9; Polyclonal Antibody; DUSP9 Rabbit Polyclonal; anti-DUSP9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 384

• Applicable Applications for anti-DUSP9 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Dual specificity phosphatase 9
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver tissue slide using MBS768803 (DUSP9 Antibody) at dilution of 1:100)

Western Blot (WB)

(mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS768803 (DUSP9 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 4503421
• NCBI GeneID: 1852
• NCBI Accession #: NP_001386.1
• NCBI GenBank Nucleotide #: NM_001395.3
• Molecular Weight: 41,868 Da
• NCBI Official Full Name: dual specificity protein phosphatase 9
• NCBI Official Synonym Full Names: dual specificity phosphatase 9
• NCBI Official Symbol: DUSP9
• NCBI Official Synonym Symbols: MKP4; MKP-4
• NCBI Protein Information: dual specificity protein phosphatase 9
• UniProt Protein Name: Dual specificity protein phosphatase 9
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP9
• UniProt Synonym Gene Names: MKP4; MAP kinase phosphatase 4; MKP-4
• UniProt Entry Name: DUS9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Description

DUSP9: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Shows selectivity for members of the ERK family, is expressed at high levels in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity

Biological Process: activation of MAPK activity; inactivation of MAPK activity; JNK cascade; MAPKKK cascade; protein amino acid dephosphorylation