Human Dual specificity protein phosphatase 9 ELISA Kit | DUSP9 elisa kit

Human Dual specificity protein phosphatase 9 ELISA Kit

Cat. Num. AAA289549

• Gene Names: DUSP9; MKP4; MKP-4
• Reactivity: Human
• Synonyms: Dual specificity protein phosphatase 9; Human Dual specificity protein phosphatase 9 ELISA Kit; Mitogen-activated protein kinase phosphatase 4; MAP kinase phosphatase 4; MKP-4; DUSP9; MKP4; 3.1.3.16; DUSP9 elisa kit

• Reactivity: Human
• Sequence Length: 384

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.12ng/mL
• Intra-Assay CV: <=4.2%
• Inter-Assay CV: <=9.3%
• Recovery: 88%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 4503421
• NCBI GeneID: 1852
• NCBI Accession #: NP_001386.1
• NCBI GenBank Nucleotide #: NM_001395.3
• UniProt Accession #: Q99956; D3DWU5
• Molecular Weight: 41,868 Da
• NCBI Official Full Name: dual specificity protein phosphatase 9
• NCBI Official Synonym Full Names: dual specificity phosphatase 9
• NCBI Official Symbol: DUSP9
• NCBI Official Synonym Symbols: MKP4; MKP-4
• NCBI Protein Information: dual specificity protein phosphatase 9
• UniProt Protein Name: Dual specificity protein phosphatase 9
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP9
• UniProt Synonym Gene Names: MKP4; MAP kinase phosphatase 4; MKP-4
• UniProt Entry Name: DUS9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Description

DUSP9: a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Shows selectivity for members of the ERK family, is expressed at high levels in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.

Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.48

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity

Biological Process: activation of MAPK activity; activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inactivation of MAPK activity; innate immune response; insulin receptor signaling pathway; JNK cascade; MAPKKK cascade; nerve growth factor receptor signaling pathway; protein amino acid dephosphorylation; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway