SDS-Page
(Gel: 12%SDS-PAGE Lysate: 40 ug, Lane 1-6: Jurkat£¬Hela£¬K562£¬293T and HepG2 cell£¬Human fetal liver tissue lysates, Primary antibody:DUSP3 antibody at dilution 1/250 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)
Rabbit anti-Human DUSP3 Polyclonal Antibody | anti-DUSP3 antibody
DUSP3 Antibody
Immunohistochemistry: 1: 20-100
SDS-Page
(Gel: 12%SDS-PAGE Lysate: 40 ug, Lane 1-6: Jurkat£¬Hela£¬K562£¬293T and HepG2 cell£¬Human fetal liver tissue lysates, Primary antibody:DUSP3 antibody at dilution 1/250 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)
SDS-Page
(Gel: 12%SDS-PAGE Lysate: 40 ug, Lane 1-6: Jurkat£¬Hela£¬K562£¬293T and HepG2 cell£¬Human fetal liver tissue lysates, Primary antibody:DUSP3 antibody at dilution 1/250 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using DUSP3 Antibody at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using DUSP3 Antibody at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using DUSP3 Antibody at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using DUSP3 Antibody at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
Uniprot Description
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Research Articles on DUSP3
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Product Notes
The DUSP3 dusp3 (Catalog #AAA9417140) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DUSP3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DUSP3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Western Blot: 1:200-1000 Immunohistochemistry: 1: 20-100. Researchers should empirically determine the suitability of the DUSP3 dusp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DUSP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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