Western Blot (WB)
(DUSP12 Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the DUSP12 antibody detected the DUSP12 protein (arrow).)
Rabbit anti-Human, mouse DUSP12 Polyclonal Antibody | anti-DUSP12 antibody
DUSP12 Antibody (Center)
Western Blot (WB)
(DUSP12 Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the DUSP12 antibody detected the DUSP12 protein (arrow).)
Western Blot (WB)
(DUSP12 Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the DUSP12 antibody detected the DUSP12 protein (arrow).)
specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They
negatively regulate members of the mitogen-activated protein (MAP)
kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated
with cellular proliferation and differentiation. Different members
of the family of dual specificity phosphatases show distinct
substrate specificities for various MAP kinases, different tissue
distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This
gene product is the human ortholog of the Saccharomyces cerevisiae
YVH1 protein tyrosine phosphatase. It is localized predominantly in
the nucleus, and is novel in that it contains, and is regulated by
a zinc finger domain.
Bonham, C.A., et al. J. Biol. Chem. 284(34):22853-22864(2009)
Sharda, P.R., et al. Biochem. J. 418(2):391-401(2009)
Gao, F., et al. Zhonghua Yi Xue Za Zhi 88(32):2250-2253(2008)
Hasstedt, S.J., et al. Ann. Hum. Genet. 72 (PT 2), 163-169 (2008) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]
Uniprot Description
DUSP12: is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: cytoplasm; nucleus
Molecular Function: zinc ion binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; kinase binding
Biological Process: protein modification process; protein amino acid dephosphorylation; positive regulation of glucokinase activity
Research Articles on DUSP12
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Product Notes
The DUSP12 dusp12 (Catalog #AAA9210844) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 162-191. The DUSP12 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's DUSP12 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the DUSP12 dusp12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DUSP12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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