Western Blot (WB)
(Western blot analysis of DUBA. Anti-DUBA antibody was used at 4 ug/ml on 1) Kidney and 2) 3T3 lysates.)
Rabbit anti-Mouse, Human DUBA Polyclonal Antibody | anti-DUBA antibody
DUBA Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of DUBA. Anti-DUBA antibody was used at 4 ug/ml on 1) Kidney and 2) 3T3 lysates.)
Western Blot (WB)
(Western blot analysis of DUBA. Anti-DUBA antibody was used at 4 ug/ml on 1) Kidney and 2) 3T3 lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Uniprot Description
OTUD5: a protein of unknown function. Contains a OTU-like cysteine protease domain.
Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.12
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: cytosol
Molecular Function: ubiquitin-specific protease activity
Biological Process: innate immune response; response to lipopolysaccharide; proteolysis; negative regulation of interferon type I production
Research Articles on DUBA
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Product Notes
The DUBA otud5 (Catalog #AAA668141) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DUBA Polyclonal Antibody reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's DUBA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 2-4 µg/ml. Researchers should empirically determine the suitability of the DUBA otud5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DUBA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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