Rabbit anti-Human, Mouse DSC3 Polyclonal Antibody | anti-DSC3 antibody

DSC3, CT (DSC3, CDHF3, DSC4, Desmocollin-3, Cadherin family member 3, Desmocollin-4, HT-CP) (FITC)

Cat. Num. AAA6293546

• Gene Names: DSC3; DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: DSC3; Polyclonal Antibody; CT (DSC3; CDHF3; DSC4; Desmocollin-3; Cadherin family member 3; Desmocollin-4; HT-CP) (FITC); HT-CP; anti-DSC3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-DSC3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: DSC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 821-850 amino acids from the C-terminal region of human DSC3.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(DSC3 Antibody (C-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the DSC3 antibody detected the DSC3 protein (arrow).)

Related Product Information for anti-DSC3 antibody

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.

Product Categories/Family for anti-DSC3 antibody

Antibodies; Cadherin

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010): Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009) Ayub, M., et al. Am. J. Hum. Genet. 85(4):515-520(2009) Aoyama, Y., et al. Exp. Dermatol. 18(4):404-408(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 148539848
• NCBI GeneID: 1825
• NCBI Accession #: NP_077741.2; NP_001932.2
• NCBI GenBank Nucleotide #: NM_024423.2
• UniProt Accession #: Q14574; Q14200; Q9HAZ9; A6NN35; Q9HAX1
• Molecular Weight: 99,969 Da
• NCBI Official Full Name: desmocollin-3 isoform Dsc3b preproprotein
• NCBI Official Synonym Full Names: desmocollin 3
• NCBI Official Symbol: DSC3
• NCBI Official Synonym Symbols: DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP
• NCBI Protein Information: desmocollin-3; desmocollin-4; cadherin family member 3
• UniProt Protein Name: Desmocollin-3
• Protein Family: Desmocollin
• UniProt Gene Name: DSC3
• UniProt Synonym Gene Names: CDHF3; DSC4
• UniProt Entry Name: DSC3_HUMAN

NCBI Description

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq]