Rabbit DPYS Polyclonal Antibody | anti-DPYS antibody

DPYS Rabbit Polyclonal

Cat. Num. AAA768758

• Gene Names: DPYS; DHP; DHPase
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: DPYS; Polyclonal Antibody; DPYS Rabbit Polyclonal; anti-DPYS antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 519

• Applicable Applications for anti-DPYS antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Dihydropyrimidinase
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver using MBS768758 (DPYS antibody) at dilution of 1:50)

Western Blot (WB)

(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS768758 (DPYS antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 823671780
• NCBI GeneID: 1807
• Molecular Weight: 56,630 Da
• NCBI Official Full Name: DPYS, partial
• NCBI Official Synonym Full Names: dihydropyrimidinase
• NCBI Official Symbol: DPYS
• NCBI Official Synonym Symbols: DHP; DHPase
• NCBI Protein Information: dihydropyrimidinase
• UniProt Protein Name: Dihydropyrimidinase
• UniProt Gene Name: DPYS
• UniProt Synonym Gene Names: DHP; DHPase
• UniProt Entry Name: DPYS_HUMAN

NCBI Description

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

Uniprot Description

DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Protein type: EC 3.5.2.2; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: cytosol

Molecular Function: amino acid binding; dihydropyrimidinase activity; phosphoprotein binding; thymine binding; uracil binding; zinc ion binding

Biological Process: beta-alanine metabolic process; protein homotetramerization; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymine catabolic process; uracil catabolic process

Disease: Dihydropyrimidinase Deficiency