Western Blot (WB)
(Western blot analysis of Dihydropyrimidinase expression in HEK293T (A), mouse liver (B), mouse brain (C), rat kidney (D) whole cell lysates.)
Rabbit Dihydropyrimidinase Polyclonal Antibody | anti-DPYS antibody
Anti-Dihydropyrimidinase Antibody
Western Blot (WB)
(Western blot analysis of Dihydropyrimidinase expression in HEK293T (A), mouse liver (B), mouse brain (C), rat kidney (D) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of Dihydropyrimidinase expression in HEK293T (A), mouse liver (B), mouse brain (C), rat kidney (D) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
Uniprot Description
DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Protein type: Other Amino Acids Metabolism - beta-alanine; EC 3.5.2.2; Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: cytosol
Molecular Function: amino acid binding; dihydropyrimidinase activity; phosphoprotein binding; thymine binding; uracil binding; zinc ion binding
Biological Process: beta-alanine metabolic process; protein homotetramerization; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymine catabolic process; uracil catabolic process
Disease: Dihydropyrimidinase Deficiency
Research Articles on DPYS
Similar Products
Product Notes
The DPYS dpys (Catalog #AAA8245776) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Dihydropyrimidinase Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Dihydropyrimidinase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1/500 - 1/2000. Researchers should empirically determine the suitability of the DPYS dpys for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dihydropyrimidinase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
