Western Blot (WB)
(Western Blot: Sample: Rat Liver lysate; Primary Ab: 2ug/mL Rabbit Anti-Rat DRD2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Rabbit anti-Rat Dopamine Receptor D2 Polyclonal Antibody | anti-DRD2 antibody
Polyclonal Antibody to Dopamine Receptor D2 (DRD2)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- SIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Rat Liver lysate; Primary Ab: 2ug/mL Rabbit Anti-Rat DRD2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Rat Liver lysate; Primary Ab: 2ug/mL Rabbit Anti-Rat DRD2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Kidney tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Kidney tissue))
NCBI and Uniprot Product Information
NCBI Description
mediates G-protein coupled signaling; may be involved in movement disorders, schizophrenia, and drug addiction [RGD, Feb 2006]
Uniprot Description
DRD2: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Defects in DRD2 are associated with dystonia type 11 (DYT11); also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 8q23
Cellular Component: acrosomal vesicle; axon; axon terminus; cell; cytoplasmic vesicle; dendrite; dendritic spine; endocytic vesicle; integral component of plasma membrane; lateral plasma membrane; membrane; perikaryon; plasma membrane; postsynaptic density; synaptic vesicle membrane
Molecular Function: adrenoceptor activity; dopamine binding; dopamine neurotransmitter receptor activity, coupled via Gi/Go; dopamine receptor activity; drug binding; G-protein coupled receptor activity; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor binding
Biological Process: acid secretion; activation of protein kinase activity; adenohypophysis development; adenylate cyclase-inhibiting dopamine receptor signaling pathway; adult behavior; adult walking behavior; arachidonic acid secretion; associative learning; auditory behavior; axonogenesis; behavioral response to cocaine; behavioral response to ethanol; branching morphogenesis of a nerve; cellular potassium ion homeostasis; cerebral cortex GABAergic interneuron migration; circadian regulation of gene expression; dopamine metabolic process; dopamine receptor signaling pathway; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; forebrain development; G-protein coupled receptor internalization; G-protein coupled receptor signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; grooming behavior; locomotory behavior; long-term memory; negative regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of circadian sleep/wake cycle, sleep; negative regulation of dopamine receptor signaling pathway; negative regulation of dopamine secretion; negative regulation of innate immune response; negative regulation of insulin secretion; negative regulation of protein kinase B signaling cascade; negative regulation of protein secretion; negative regulation of synaptic transmission, glutamatergic; nerve-nerve synaptic transmission; neurological system process involved in regulation of systemic arterial blood pressure; orbitofrontal cortex development; peristalsis; phosphatidylinositol metabolic process; phospholipase C-activating dopamine receptor signaling pathway; pigmentation; positive regulation of cytokinesis; positive regulation of dopamine uptake involved in synaptic transmission; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of growth hormone secretion; positive regulation of mitotic nuclear division; positive regulation of multicellular organism growth; positive regulation of neuroblast proliferation; positive regulation of receptor internalization; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; protein localization; reduction of cytosolic calcium ion concentration; regulation of cAMP metabolic process; regulation of dopamine secretion; regulation of dopamine uptake; regulation of heart rate; regulation of long-term neuronal synaptic plasticity; regulation of MAPK cascade; regulation of phosphoprotein phosphatase activity; regulation of potassium ion transport; regulation of sodium ion transport; regulation of synapse structural plasticity; regulation of synaptic transmission; regulation of synaptic transmission, GABAergic; release of sequestered calcium ion into cytosol; response to amphetamine; response to axon injury; response to cocaine; response to drug; response to ethanol; response to hypoxia; response to inactivity; response to iron ion; response to light stimulus; response to morphine; response to nicotine; response to toxin; sensory perception of smell; startle response; striatum development; synaptic transmission, dopaminergic; synaptogenesis; thermoregulation; visual learning; Wnt signaling pathway
Research Articles on DRD2
Similar Products
Product Notes
The DRD2 drd2 (Catalog #AAA2027102) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Dopamine Receptor D2 (DRD2) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Dopamine Receptor D2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the DRD2 drd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- SIVSFYV PFIVTLLVYI KIYIVLRKRR KRVNTKRSSR AFRANLKTPL KGNCTHPEDM KLCTVIMKSN GSFPVNRRRM DAARRAQELE MEMLSSTSPP ERTRYSPIPP SHHQLTLPDP SHHGLHSNPD SPAKPEKNGH AKIVNPRIAK FFEIQTMPNG KTRTSLKTMS RRKLSQQKEK KATQMLAIVL GVFIICWLPF. It is sometimes possible for the material contained within the vial of "Dopamine Receptor D2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
