Mouse anti-Human MAP3K2 Monoclonal Antibody | anti-MAP3K2 antibody

Anti-MAP3K2 Mouse mAb

Cat. Num. AAA476218

• Gene Names: MAP3K2; MEKK2; MEKK2B
• Reactivity: Human
• Applications: Western Blot, Immunocytochemistry
• Synonyms: MAP3K2; Monoclonal Antibody; Anti-MAP3K2 Mouse mAb; MEKK2; MEKK2B; anti-MAP3K2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 4B4
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 234

• Applicable Applications for anti-MAP3K2 antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Immunogen: Purified recombinant fragment of human MAP3K2 expressed in E Coli.

Western Blot (WB)

(Western blot analysis using MAP3K2 mAb against human MAP3K2 (AA)

Western Blot (WB)

(Western blot analysis using MAP3K2 mAb against HEK293 (1) and MAP3K2 (AA)

Immunofluorescence (IF)

(Immunofluorescence analysis of 3T3-L1 cells using MAP3K2 mouse mAb (green). Blue)

Related Product Information for anti-MAP3K2 antibody

Entrez Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.

NCBI and Uniprot Product Information

• NCBI GI #: 41388990
• NCBI GeneID: 10746
• Molecular Weight: 70
• NCBI Official Full Name: MAP3K2 protein, partial
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 2
• NCBI Official Symbol: MAP3K2
• NCBI Official Synonym Symbols: MEKK2; MEKK2B
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 2
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 2
• UniProt Gene Name: MAP3K2
• UniProt Synonym Gene Names: MAPKKK2; MEKK2; MEK kinase 2; MEKK 2

NCBI Description

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Uniprot Description

MEKK2: a protein kinase of the STE11 family. Phosphorylates and activates MEK5. Involved in growth factor stimulated cell proliferation and differentiation.

Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family

Chromosomal Location of Human Ortholog: 2q14.3

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of JNK activity; activation of MAPK activity; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation