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TSC22D1 recombinant protein

TSC22D1 Protein, Mouse, Recombinant (His Tag)

Gene Names
Tsc22d1; Tsc; Egr5; Tsc22; TSC-22; Tgfb1i4; AA589566; AW105905
Purity
>90% as determined by SDS-PAGE
Synonyms
TSC22D1; TSC22D1 Protein; Mouse; Recombinant (His Tag); Mouse TSC22D1 Protein (His Tag); AA589566 Protein; AW105905 Protein; Egr5 Protein; Tgfb1i4 Protein; Tsc Protein; TSC-22 Protein; Tsc22 Protein; TSC22 domain family; member 1; TSC22D1 recombinant protein
Ordering
For Research Use Only!
Host
E Coli
Purity/Purification
>90% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Ala143
Species
Mouse
Predicted N Terminal
Met
Tag
N-His
Protein Construction
A DNA sequence encoding the mouse Tsc22d1 (NP_033392.1)(Met1-Ala143) was expressed with a polyhistidine tag at the N-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.

SDS-Page

SDS-Page
Related Product Information for TSC22D1 recombinant protein
Background: TSC22 domain family, member 1 (TSC22D1) is one of the TGF-beta-stimulated clone-22 (TSC-22). TSC-22 was reported to be a differentiation-inducing factor that negatively regulates the growth of salivary gland cancer cells. TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors. TSC-22 may play an important role in maintaining the differentiated phenotype in salivary gland tumors, and may be a possible target of leukemia therapy. TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.
References
Doi Y, et al. (2008) Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: implications for tumor cell differentiation. Oncol Rep. 19(3): 609-16.Wu X, et al. (2008) The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival. Proc Natl Acad Sci U S A. 105(14): 5414-9.Lu Y, et al. (2007) Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia. 21(11): 2246-57.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
102,086 Da
NCBI Official Full Name
TSC22 domain family protein 1 isoform 2
NCBI Official Synonym Full Names
TSC22 domain family, member 1
NCBI Official Symbol
Tsc22d1
NCBI Official Synonym Symbols
Tsc; Egr5; Tsc22; TSC-22; Tgfb1i4; AA589566; AW105905
NCBI Protein Information
TSC22 domain family protein 1
UniProt Protein Name
TSC22 domain family protein 1
UniProt Gene Name
Tsc22d1
UniProt Synonym Gene Names
Kiaa1994; Tgfb1i4; Tilz1b; Tsc22
UniProt Entry Name
T22D1_MOUSE

Uniprot Description

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

Research Articles on TSC22D1

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Product Notes

The TSC22D1 tsc22d1 (Catalog #AAA8123201) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Ala14 3. It is sometimes possible for the material contained within the vial of "TSC22D1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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