Rabbit DEDD2 Polyclonal Antibody | anti-DEDD2 antibody

DEDD2 antibody

Cat. Num. AAA536072

• Gene Names: DEDD2; FLAME-3
• Reactivity: To be determined by end-user
• Applications: User optimized
• Synonyms: DEDD2; Polyclonal Antibody; DEDD2 antibody; Polyclonal DEDD2; Anti-DEDD2; DEDD 2; DEDD -2; Death Effector Domain-containing DNA-binding Protein; anti-DEDD2 antibody

• Host: Rabbit
• Reactivity: To be determined by end-user
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Supplied as serum containing 0.02% NaN3.
• Sequence Length: 326

• Applicable Applications for anti-DEDD2 antibody: User optimized
• Biological Significance: Death Effector Domain-containing protein, DEDD2, is closest in amino acid sequence homology to Death Effector Domain-containing DNA-binding protein, DEDD. DEDD2 is expressed widely in adult human tissues with highest levels in liver, kidney and peripheral blood leukocytes.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Immunogen: DEDD2 antibody was raised in rabbit using residues 144-129 of the DEDD2 protein as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-DEDD2 antibody

Rabbit polyclonal DEDD2 antibody

Product Categories/Family for anti-DEDD2 antibody

Cell Cycle & Cell Death

NCBI and Uniprot Product Information

• NCBI GI #: 19923050
• NCBI GeneID: 162989
• NCBI Accession #: NP_579874
• NCBI GenBank Nucleotide #: NM_133328.3
• UniProt Accession #: Q8WXF8; Q8NBR2; Q8NES1; Q8TAA8; Q96D35
• Molecular Weight: 35,577 Da
• NCBI Official Full Name: DNA-binding death effector domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: death effector domain containing 2
• NCBI Official Symbol: DEDD2
• NCBI Official Synonym Symbols: FLAME-3
• NCBI Protein Information: DNA-binding death effector domain-containing protein 2
• UniProt Protein Name: DNA-binding death effector domain-containing protein 2
• Protein Family: DNA-binding death effector domain-containing protein
• UniProt Gene Name: DEDD2
• UniProt Synonym Gene Names: FLAME3
• UniProt Entry Name: DEDD2_HUMAN

NCBI Description

This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Description

DEDD2: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleoplasm; nucleolus

Molecular Function: protein binding; receptor signaling complex scaffold activity; DNA binding

Biological Process: RNA processing; transcription, DNA-dependent; induction of apoptosis via death domain receptors; apoptotic nuclear changes; rRNA catabolic process; cellular homeostasis; negative regulation of transcription, DNA-dependent