Rabbit DDX6 Polyclonal Antibody | anti-DDX6 antibody

DDX6 Antibody BIOTIN-Conjugated

Cat. Num. AAA541410

• Gene Names: DDX6; P54; RCK; HLR2
• Reactivity: Chicken, Human, Mouse, Rat
• Applications: Dot Blot, ELISA, Western Blot
• Synonyms: DDX6; Polyclonal Antibody; DDX6 Antibody BIOTIN-Conjugated; ATP dependent RNA helicase DDX6; ATP dependent RNA helicase p54; DEAD (Asp Glu Ala Asp) box polypeptide 6; DEAD box 6; DEAD box protein 6; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase 54kD); FLJ36338; HLR2; Oncogene RCK; P54; Probable ATP-dependent RNA helicase DDX6; RCK antibody; anti-DDX6 antibody

• Host: Rabbit
• Reactivity: Chicken, Human, Mouse, Rat
• Clonality: Polyclonal
• Form/Format: BIOTIN-Conjugated
• Concentration: 0.68-0.70 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 483

• Applicable Applications for anti-DDX6 antibody: Dot Blot (DB), ELISA (EIA), IMM, Western Blot (WB)
• Application Notes: Dot Blot: 1:4,000; ELISA: 1:4,000; Immunoprecipitation: 1:150; Western Blot: 1:500
• Immunogen: Synthetic peptide taken within amino acid region 433-483 on probable ATP-dependent RNA helicase DDX6 protein.
• Expression: Abundantly expressed in most tissues.
• Molecular Function: ATP-binding, Nucleotide-binding, RNA-binding
• Structure: Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with RC3H1 (By similarity).
• Subcellular Location: Cytoplasm; P-body
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-DDX6 antibody

BIOTIN-Conjugated Probable ATP-dependent RNA helicase DDX6 Antibody
In the process of mRNA degradation, may play a role in mRNA decapping.

NCBI and Uniprot Product Information

• NCBI GI #: 164664518
• NCBI GeneID: 1656
• NCBI Accession #: NP_004388.2
• NCBI GenBank Nucleotide #: NM_004397.5
• UniProt Accession #: P26196; Q5D048
• Molecular Weight: 54,417 Da
• NCBI Official Full Name: probable ATP-dependent RNA helicase DDX6
• NCBI Official Synonym Full Names: DEAD-box helicase 6
• NCBI Official Symbol: DDX6
• NCBI Official Synonym Symbols: P54; RCK; HLR2
• NCBI Protein Information: probable ATP-dependent RNA helicase DDX6
• UniProt Protein Name: Probable ATP-dependent RNA helicase DDX6
• Protein Family: ATP-dependent RNA helicase
• UniProt Gene Name: DDX6
• UniProt Synonym Gene Names: HLR2; RCK
• UniProt Entry Name: DDX6_HUMAN

NCBI Description

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

Uniprot Description

DDX6: an oncogenic ATP-dependent helicase of the DEAD box family. Interacts with argonaute proteins, Ago1 and Ago2, and is a general repressor of translation in human cells by miRNA-induced gene silencing. In the process of mRNA degradation, may play a role in mRNA decapping.

Protein type: Oncoprotein; Helicase; EC 3.6.4.13; RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; membrane; stress granule

Molecular Function: ATP binding; ATP-dependent RNA helicase activity; helicase activity; protein binding; protein domain specific binding; RNA helicase activity

Biological Process: cytoplasmic mRNA processing body assembly; negative regulation of neuron differentiation; regulation of translation; RNA secondary structure unwinding; stem cell maintenance; viral RNA genome packaging