Rabbit DcR3 Polyclonal Antibody

DcR3, NT (TR6, Decoy Receptor 3, TNFRSF6B, TR6, M68)

Cat. Num. AAA614791

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Purified; Purified IgG
• Synonyms: DcR3; Polyclonal Antibody; NT (TR6; Decoy Receptor 3; TNFRSF6B; TR6; M68); Anti -DcR3; anti-DcR3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: An approximately 33kD band can be detected. Human, mouse and rat reactive.
• Purity/Purification: Purified; Purified IgG
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-DcR3 antibody: Western Blot (WB)
• Immunogen: Peptide corresponding to amino acids 31 to 46 of human DcR3 precursor (1,2).
• Preparation and Storage: -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of MBS614791.)

Testing Data

Related Product Information for anti-DcR3 antibody

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively, (1,2). Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis (1,2). DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.

Product Categories/Family for anti-DcR3 antibody

Antibodies; Abs to Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 37545624
• NCBI Official Full Name: decoy receptor 3 variant 2

NCBI Description

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Uniprot Description

TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function: protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis