Rabbit anti-Human, Mouse DAB2IP Polyclonal Antibody | anti-DAB2IP antibody

DAB2IP Rabbit Polyclonal

Cat. Num. AAA768461

• Gene Names: DAB2IP; AIP1; AIP-1; AF9Q34; DIP1/2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: DAB2IP; Polyclonal Antibody; DAB2IP Rabbit Polyclonal; anti-DAB2IP antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1132

• Applicable Applications for anti-DAB2IP antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: DAB2 interacting protein
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Testing Data

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Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS768461 (DAB2IP Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 94967023
• NCBI GeneID: 153090
• NCBI Accession #: NP_115941.2
• NCBI GenBank Nucleotide #: NM_032552.3
• Molecular Weight: 125,041 Da
• NCBI Official Full Name: disabled homolog 2-interacting protein isoform 1
• NCBI Official Synonym Full Names: DAB2 interacting protein
• NCBI Official Symbol: DAB2IP
• NCBI Official Synonym Symbols: AIP1; AIP-1; AF9Q34; DIP1/2
• NCBI Protein Information: disabled homolog 2-interacting protein
• UniProt Protein Name: Disabled homolog 2-interacting protein
• Protein Family: Disabled homolog 2-interacting protein
• UniProt Gene Name: DAB2IP
• UniProt Synonym Gene Names: AF9Q34; AIP1; KIAA1743; DAB2 interaction protein; DAB2-interacting protein; AIP-1
• UniProt Entry Name: DAB2P_HUMAN

NCBI Description

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

Uniprot Description

DAB2IP: a Ras GTPase-activating protein (GAP) for ARF6 and Ras. Has tumor suppressor activity. Through its interaction with ASK1 disrupts the association of ASK1 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced ASK1-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5. A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Ras; Tumor suppressor

Chromosomal Location of Human Ortholog: 9q33.1-q33.3

Cellular Component: axon; cell soma; cell-cell adherens junction; cytoplasm; cytosol; endocytic vesicle; plasma membrane

Molecular Function: death receptor binding; GTPase activator activity; identical protein binding; kinase binding; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; phosphatidylinositol 3-phosphate binding; phosphoinositide 3-kinase binding; protein binding; protein complex binding; protein homodimerization activity; protein kinase binding; protein phosphatase 2A binding; SH3 domain binding; vascular endothelial growth factor receptor 2 binding

Biological Process: activation of JNK activity; activation of MAPKKK activity; cell locomotion involved in cerebral cortex radial glia guided migration; cellular protein catabolic process; I-kappaB phosphorylation; induction of apoptosis via death domain receptors; inhibition of NF-kappaB transcription factor; layer formation in the cerebral cortex; lumen formation; MAPKKK cascade; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of MAP kinase activity; negative regulation of phosphoinositide 3-kinase activity; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein amino acid phosphorylation; negative regulation of Ras protein signal transduction; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of vascular endothelial growth factor receptor signaling pathway; neurite morphogenesis; positive regulation of apoptosis; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of GTPase activity; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of protein complex assembly; regulation of protein heterodimerization activity; unfolded protein response, activation of signaling protein activity