Chemiluminescence
(EB07476 (0.5µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat anti-Mouse D130043K22Rik Polyclonal Antibody | anti-D130043K22Rik antibody
D130043K22Rik (Similar to KIAA0319 Gene Product, 4930451E12Rik, KIAA0319, mKIAA0319)
Purified by affinity chromatography.
Purified by affinity chromatography.
Dilution: ELISA: 1:128,000
Chemiluminescence
(EB07476 (0.5µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Chemiluminescence
(EB07476 (0.5µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in a similar gene in human are associated with dyslexia. Alternatively spliced transcript variants have been identifed. [provided by RefSeq, May 2015]
Uniprot Description
KIAA0319: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. Defects in KIAA0319 may be a cause of susceptibility to dyslexia type 2 (DYX2); also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. A lower expression is associated with the risk haplotype. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Cellular Component: membrane; early endosome; integral to membrane; plasma membrane; endosome
Biological Process: nervous system development; multicellular organismal development; neuron migration
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Product Notes
The D130043K22Rik kiaa0319 (Catalog #AAA619420) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The D130043K22Rik (Similar to KIAA0319 Gene Product, 4930451E12Rik, KIAA0319, mKIAA0319) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's D130043K22Rik can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:128,000. Researchers should empirically determine the suitability of the D130043K22Rik kiaa0319 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "D130043K22Rik, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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