Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat pancreas using CYP24A1 antibody.)
Rabbit CYP24A1 Polyclonal Antibody | anti-CYP24A1 antibody
CYP24A1 Polyclonal Antibody
IF: 1:50-1:100
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat pancreas using CYP24A1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded rat pancreas using CYP24A1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse kidney using CYP24A1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse kidney using CYP24A1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver cancer using CYP24A1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human liver cancer using CYP24A1 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of NIH-3T3 cells using CYP24A1 Polyclonal Antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of NIH-3T3 cells using CYP24A1 Polyclonal Antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP24A1: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. Defects in CYP24A1 are the cause of hypercalcemia infantile (HCAI). HCAI is a disorder characterized by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; EC 1.14.13.126; Oxidoreductase
Chromosomal Location of Human Ortholog: 20q13
Cellular Component: mitochondrial inner membrane
Molecular Function: iron ion binding; heme binding; 25-hydroxycholecalciferol-24-hydroxylase activity; oxidoreductase activity; 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity
Biological Process: osteoblast differentiation; steroid metabolic process; response to vitamin D; vitamin metabolic process; xenobiotic metabolic process; vitamin D catabolic process; vitamin D metabolic process
Disease: Hypercalcemia, Infantile
Research Articles on CYP24A1
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Product Notes
The CYP24A1 cyp24a1 (Catalog #AAA9433406) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CYP24A1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CYP24A1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF). IHC: 1:50-1:100 IF: 1:50-1:100. Researchers should empirically determine the suitability of the CYP24A1 cyp24a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP24A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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