Immunofluorescence (IF)
(Confocal immunofluorescent analysis of CYP17A1 Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Rabbit anti-Human CYP17A1 Polyclonal Antibody | anti-CYP17A1 antibody
CYP17A1, ID (Steroid 17-alpha-hydroxylase/17,20 Lyase, Steroid 17-alpha-Monooxygenase, Cytochrome P450-C17, Cytochrome P450c17, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, CYP17, S17AH) (MaxLight 750)
FLISA: 1:1,000
Applications are based on unconjugated antibody.
Immunofluorescence (IF)
(Confocal immunofluorescent analysis of CYP17A1 Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis of CYP17A1 Antibody (Center) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Western Blot (WB)
(Western blot analysis of anti-CYP17A1 Antibody (Center) in K562 cell line lysates (35ug/lane). CYP17A1(arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-CYP17A1 Antibody (Center) in K562 cell line lysates (35ug/lane). CYP17A1(arrow) was detected using the purified Pab.)
NCBI and Uniprot Product Information
Uniprot Description
CYP17A1: Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5). AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: salt wasting (SW, the most severe type), simple virilizing (SV, less severely affected patients), with normal aldosterone biosynthesis, non-classic form or late onset (NC or LOAH), and cryptic (asymptomatic). Belongs to the cytochrome P450 family.
Protein type: EC 4.1.2.30; EC 1.14.99.9; Oxidoreductase; Lipid Metabolism - C21-steroid hormone
Chromosomal Location of Human Ortholog: 10q24.3
Cellular Component: endoplasmic reticulum membrane; cell soma; mitochondrion; endoplasmic reticulum; axon
Molecular Function: 17-alpha-hydroxyprogesterone aldolase activity; steroid 17-alpha-monooxygenase activity; iron ion binding; heme binding; oxygen binding
Biological Process: steroid metabolic process; response to cAMP; dibenzo-p-dioxin metabolic process; androgen biosynthetic process; progesterone metabolic process; response to insecticide; Leydig cell differentiation; biphenyl metabolic process; response to methylmercury; hormone biosynthetic process; response to drug; response to nutrient levels; response to retinoic acid; adrenal gland development; phthalate metabolic process; hippocampus development; response to herbicide; ovulation; response to acetate; response to steroid hormone stimulus; xenobiotic metabolic process; response to cytokine stimulus; response to ionizing radiation; glucocorticoid biosynthetic process; sex differentiation; sterol metabolic process; steroid biosynthetic process; phenol metabolic process
Disease: Adrenal Hyperplasia, Congenital, Due To 17-alpha-hydroxylase Deficiency
Similar Products
Product Notes
The CYP17A1 cyp17a1 (Catalog #AAA6471293) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CYP17A1, ID (Steroid 17-alpha-hydroxylase/17,20 Lyase, Steroid 17-alpha-Monooxygenase, Cytochrome P450-C17, Cytochrome P450c17, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, CYP17, S17AH) (MaxLight 750) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CYP17A1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:50-1:100 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the CYP17A1 cyp17a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP17A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
