Rabbit Cyclin D1 Polyclonal Antibody | anti-CCND1 antibody

Cyclin D1

Cat. Num. AAA8565207

• Gene Names: Ccnd1; cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI327039
• Reactivity: Human, Mouse, Rat
• Purity: Peptide Affinity Purified
• Synonyms: Cyclin D1; Polyclonal Antibody; G1/S-specific cyclin-D1; anti-CCND1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Peptide Affinity Purified
• Form/Format: 1*TBS (pH7.4), 1% BSA, 40% Glycerol. 0.05% Sodium Azide.
• Sequence Length: 295

• Immunogen: Peptide
• Preparation and Storage: Store at 4 degree C after thawing. Aliquot store at -20 degree C or -80 degree C. Avoid repeated freeze/thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 116153
• NCBI GeneID: 12443
• UniProt Accession #: P25322
• NCBI Official Full Name: G1/S-specific cyclin-D1
• NCBI Official Synonym Full Names: cyclin D1
• NCBI Official Symbol: Ccnd1
• NCBI Official Synonym Symbols: cD1; CycD1; Cyl-1; PRAD1; bcl-1; AI327039
• NCBI Protein Information: G1/S-specific cyclin-D1
• UniProt Protein Name: G1/S-specific cyclin-D1
• Protein Family: G1/S-specific cyclin
• UniProt Gene Name: Ccnd1
• UniProt Synonym Gene Names: Cyl-1
• UniProt Entry Name: CCND1_MOUSE

Uniprot Description

CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.

Protein type: Nuclear receptor co-regulator; Activator; Cell cycle regulation; Oncoprotein

Cellular Component: nucleoplasm; tight junction; membrane; transcriptional repressor complex; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; intracellular; nucleus

Molecular Function: protein binding; enzyme binding; histone deacetylase binding; protein complex binding; kinase activity; cyclin-dependent protein kinase regulator activity; transcription corepressor activity; transcription factor binding; protein kinase binding; protein kinase activity

Biological Process: lactation; fat cell differentiation; G1 DNA damage checkpoint; negative regulation of Wnt receptor signaling pathway; re-entry into mitotic cell cycle; positive regulation of cyclin-dependent protein kinase activity; regulation of cell cycle; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; Leydig cell differentiation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; Wnt receptor signaling pathway; transcription, DNA-dependent; unfolded protein response; mammary gland epithelial cell proliferation; response to organic nitrogen; cell cycle; cell division; positive regulation of protein amino acid phosphorylation; regulation of cyclin-dependent protein kinase activity; regulation of protein kinase activity; response to DNA damage stimulus; G1/S transition of mitotic cell cycle