Rabbit CXADR Polyclonal Antibody | anti-CXADR antibody

Rabbit Polyclonal (IgG) to Human CXADR

Cat. Num. AAA248308

• Gene Names: CXADR; CAR; HCAR; CAR4/6
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: CXADR; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human CXADR; Anti-CXADR Antibody (aa1-50) IHC-plus; CAR4/6; Coxsackie-adenovirus receptor; CVB3-binding protein; CAR; HCAR; HCVADR; Human CXADR; anti-CXADR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CXADR Antibody detects endogenous levels of total CXADR protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 365

• Applicable Applications for anti-CXADR antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:20000), IHC-P (5 - 20 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human CXADR (aa1-50).
• Immunogen: CXADR antibody was raised against synthetic peptide from human CXADR (aa1-50).
• Antigen Modification: aa1-50
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-CXADR antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(Western blot of extracts from HepG2/COLO cells, using CXADR Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-CXADR antibody

The Coxsackievirus and adenovirus receptor (CAR) is a membrane glycoprotein with a cytoplasmic domain, a transmembrane domain and an extracellular region consisting of two immunoglobulin-like domains, an amino-terminal immunoglobulin variable (IgV)-related domain (D1), which is distal to the cell surface, and a proximal IgC2 domain (D2). The Coxsackievirus and adenovirus receptor has been shown to exhibit tumor suppression activity in human bladder and prostate cancer cells.

NCBI and Uniprot Product Information

• NCBI GI #: 4503173
• NCBI GeneID: 1525
• NCBI Accession #: NP_001329.1
• NCBI GenBank Nucleotide #: NM_001338.4
• UniProt Accession #: P78310; O00694; Q8WWT6; Q8WWT7; Q8WWT8; Q9UKV4; B2R8V8; B7WPI3; D3YHP0
• Molecular Weight: 35,570 Da
• NCBI Official Full Name: coxsackievirus and adenovirus receptor isoform 1
• NCBI Official Synonym Full Names: coxsackie virus and adenovirus receptor
• NCBI Official Symbol: CXADR
• NCBI Official Synonym Symbols: CAR; HCAR; CAR4/6
• NCBI Protein Information: coxsackievirus and adenovirus receptor; HCVADR; CVB3-binding protein; coxsackievirus B-adenovirus receptor; 46 kD coxsackievirus and adenovirus receptor (CAR) protein
• UniProt Protein Name: Coxsackievirus and adenovirus receptor
• Protein Family: CXADR-like membrane protein
• UniProt Gene Name: CXADR
• UniProt Synonym Gene Names: CAR; CAR; hCAR
• UniProt Entry Name: CXAR_HUMAN

NCBI Description

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]

Uniprot Description

CXADR: a component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1 located in the plasma membrane of PMN.

Protein type: Membrane protein, integral; Cell adhesion; Receptor, misc.

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: extracellular space; neuron projection; protein complex; tight junction; integral to plasma membrane; basolateral plasma membrane; apicolateral plasma membrane; extracellular region; acrosome; intercellular junction; lipid raft; nucleoplasm; adherens junction; growth cone; plasma membrane; neuromuscular junction; cell junction; filopodium

Molecular Function: viral receptor activity; integrin binding; identical protein binding; protein binding; beta-catenin binding; cell adhesion molecule binding; receptor binding; PDZ domain binding

Biological Process: intercellular junction assembly and maintenance; mitochondrion organization and biogenesis; neutrophil chemotaxis; regulation of immune response; entry of virus into host cell; heart development; gamma-delta T cell activation; heterophilic cell adhesion; cardiac muscle fiber development; germ cell migration; actin cytoskeleton reorganization; homotypic cell-cell adhesion; blood coagulation; leukocyte migration; defense response to virus