Western Blot (WB)
(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: A431 cell, Primary antibody: 120493(CUL7 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds)
Rabbit anti-Human Cullin 7/CUL-7 Polyclonal Antibody | anti-CUL-7 antibody
Cullin 7/CUL-7 Rabbit pAb
Western Blot (WB)
(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: A431 cell, Primary antibody: 120493(CUL7 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds)
Western Blot (WB)
(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: A431 cell, Primary antibody: 120493(CUL7 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 120493(CUL7 Antibody) at dilution 1/35. (Original magnification: ×200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 120493(CUL7 Antibody) at dilution 1/35. (Original magnification: ×200))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Description
CUL7: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. Belongs to the cullin family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: nucleoplasm; Golgi apparatus; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: ubiquitin-dependent protein catabolic process; viral reproduction; unfolded protein response; protein ubiquitination; microtubule cytoskeleton organization and biogenesis; positive regulation of dendrite morphogenesis; proteolysis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cytokinesis after mitosis; epithelial to mesenchymal transition; regulation of mitosis; vasculogenesis; Golgi organization and biogenesis; placenta development
Disease: Three M Syndrome 1
Research Articles on CUL-7
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Product Notes
The CUL-7 cul7 (Catalog #AAA4754264) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cullin 7/CUL-7 Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cullin 7/CUL-7 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:200-1:1000. Researchers should empirically determine the suitability of the CUL-7 cul7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cullin 7/CUL-7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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