Rabbit CTBP2 Polyclonal Antibody | anti-CTBP2 antibody

Anti-CTBP2 Antibody (aa396-445) IHC-plus

Cat. Num. AAA2400348

• Reactivity: Mouse, Rat, Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity purified
• Synonyms: CTBP2; Polyclonal Antibody; Anti-CTBP2 Antibody (aa396-445) IHC-plus; Rabbit Polyclonal (IgG) to Human CTBP2; Human CTBP2; C-terminal-binding protein 2; C-terminal binding protein 2; Ribeye; anti-CTBP2 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat, Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CtBP2 Antibody detects endogenous levels of total CtBP2 protein.
• Purity/Purification: Immunoaffinity purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 985

• Applicable Applications for anti-CTBP2 antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:1000); IHC-P (10 ug/ml); WB (1:500 - 1:1000)
• Immunogen: CTBP2 antibody was raised against synthetic peptide from human CtBP2 (aa396-445).
• Immunogen Description: Synthetic peptide from human CtBP2 (aa396-445).
• Antigen Modification: aa396-445
• Target Species: Human
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-CTBP2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Western blot of extracts from HeLa/293 cells, using CtBP2 Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-CTBP2 antibody

CTBP2 Antibody, C-terminal-binding protein 2 Antibody, C-terminal binding protein 2 Antibody, Ribeye Antibody Description: This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely.

NCBI and Uniprot Product Information

• NCBI GI #: 145580575
• NCBI GeneID: 1488
• NCBI Accession #: NP_073713.2
• NCBI GenBank Nucleotide #: NM_022802.2
• UniProt Accession #: P56545; O43449; Q5SQP7; Q69YI3; Q86SV0; Q9H2T8; A8K2X5; D3DRF5
• Molecular Weight: 106,187 Da
• NCBI Official Full Name: C-terminal-binding protein 2 isoform 2
• NCBI Official Synonym Full Names: C-terminal binding protein 2
• NCBI Official Symbol: CTBP2
• NCBI Protein Information: C-terminal-binding protein 2
• UniProt Protein Name: C-terminal-binding protein 2
• Protein Family: C-terminal-binding protein
• UniProt Gene Name: CTBP2
• UniProt Synonym Gene Names: CtBP2
• UniProt Entry Name: CTBP2_HUMAN

NCBI Description

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Uniprot Description

CTBP2: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: cell junction; nucleus; transcriptional repressor complex

Molecular Function: chromatin binding; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein binding; protein homodimerization activity; retinoic acid receptor binding; transcription coactivator activity; transcription corepressor activity

Biological Process: negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral genome replication; white fat cell differentiation