Rabbit anti-Human CTBP2 Polyclonal Antibody | anti-CTBP2 antibody

CTBP2 Antibody

Cat. Num. AAA9402487

• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: CTBP2; Polyclonal Antibody; CTBP2 Antibody; ribeye; C-terminal-binding protein 2; anti-CTBP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total CTBP2 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.8 mg/ml (varies by lot)
• Sequence Length: 445

• Applicable Applications for anti-CTBP2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500-1:2000; Immunohistochemistry: 1:25-1:100
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to residues near the C terminal of human C-terminal binding protein 2
• Target Name: CTBP2
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 8%SDS-PAGE Lysate: 40ug PC3 cell Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/25.)

Related Product Information for anti-CTBP2 antibody

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.

Product Categories/Family for anti-CTBP2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 145580578
• NCBI GeneID: 1488
• NCBI Accession #: NP_001077383.1
• NCBI GenBank Nucleotide #: NM_001083914.1
• UniProt Accession #: P56545; O43449; Q5SQP7; Q69YI3; Q86SV0; Q9H2T8; A8K2X5; D3DRF5
• Molecular Weight: 106,187 Da
• NCBI Official Full Name: C-terminal-binding protein 2 isoform 1
• NCBI Official Synonym Full Names: C-terminal binding protein 2
• NCBI Official Symbol: CTBP2
• NCBI Protein Information: C-terminal-binding protein 2
• UniProt Protein Name: C-terminal-binding protein 2
• Protein Family: C-terminal-binding protein
• UniProt Gene Name: CTBP2
• UniProt Synonym Gene Names: CtBP2
• UniProt Entry Name: CTBP2_HUMAN

NCBI Description

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Uniprot Description

CTBP2: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: transcriptional repressor complex; synapse; nucleus; cell junction

Molecular Function: protein binding; retinoic acid receptor binding; transcription coactivator activity; chromatin binding; NAD binding; transcription corepressor activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; white fat cell differentiation; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; viral genome replication; negative regulation of transcription, DNA-dependent