Western Blot (WB)
(CRUM2 Antibody (C-term) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the CRUM2 antibody detected CRUM2 protein (arrow).)
Rabbit anti-Human, mouse CRUM2 Polyclonal Antibody | anti-CRB2 antibody
CRUM2 Antibody (C-term)
Western Blot (WB)
(CRUM2 Antibody (C-term) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the CRUM2 antibody detected CRUM2 protein (arrow).)
Western Blot (WB)
(CRUM2 Antibody (C-term) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the CRUM2 antibody detected CRUM2 protein (arrow).)
Immunohistochemistry (IHC)
(CRUM2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CRUM2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(CRUM2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CRUM2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Location: Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart.
NCBI and Uniprot Product Information
Uniprot Description
CRB2: May play a role in polarized cells morphogenesis. Belongs to the Crumbs protein family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q33.3
Cellular Component: protein complex; integral to membrane; plasma membrane; lipid raft
Molecular Function: enzyme binding; aspartic-type endopeptidase inhibitor activity; calcium ion binding
Biological Process: somitogenesis; mesoderm formation; notochord formation; maintenance of epithelial cell polarity; positive regulation of BMP signaling pathway
Disease: Ventriculomegaly With Cystic Kidney Disease; Focal Segmental Glomerulosclerosis 9
Research Articles on CRB2
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Product Notes
The CRB2 crb2 (Catalog #AAA9207250) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1258-1285. The CRUM2 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CRUM2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). WB: 1:1000; IHC-P: 1:50~100. Researchers should empirically determine the suitability of the CRB2 crb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRUM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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