Western Blot (WB)
(Western blot analysis of CRIPTO (TDGF1) Antibody (N-term) in Jurkat cell line lysates (35ug/lane). TDGF1 (arrow) was detected using the purified Pab.)
Rabbit anti-Human CRIPTO (TDGF1) Polyclonal Antibody | anti-TDGF1 antibody
CRIPTO (TDGF1) Antibody (N-term)
IHC-P~~1:50~100
Western Blot (WB)
(Western blot analysis of CRIPTO (TDGF1) Antibody (N-term) in Jurkat cell line lysates (35ug/lane). TDGF1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of CRIPTO (TDGF1) Antibody (N-term) in Jurkat cell line lysates (35ug/lane). TDGF1 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Gray, P.C., et al., Proc. Natl. Acad. Sci. U.S.A. 100(9):5193-5198 (2003).
Yan, Y.T., et al., Mol. Cell. Biol. 22(13):4439-4449 (2002).
de la Cruz, J.M., et al., Hum. Genet. 110(5):422-428 (2002).
Dono, R., et al., Am. J. Hum. Genet. 49(3):555-565 (1991).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Description
TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
Protein type: Membrane protein, GPI anchor; Cell adhesion; Cell cycle regulation; Motility/polarity/chemotaxis; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: extrinsic to plasma membrane; Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; nucleus; lipid raft
Molecular Function: protein binding; growth factor activity; receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; somatic stem cell maintenance; activation of MAPK activity; in utero embryonic development; heart development; regulation of signal transduction; gastrulation; Wnt receptor signaling pathway through beta-catenin; morphogenesis of a branching structure; cardiac muscle cell differentiation; BMP signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; embryonic development; peptidyl-serine phosphorylation; positive regulation of fibroblast proliferation; mammary gland development; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; vasculogenesis; positive regulation of cell-matrix adhesion; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on TDGF1
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Product Notes
The TDGF1 tdgf1 (Catalog #AAA9212907) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 18-48. The CRIPTO (TDGF1) Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CRIPTO (TDGF1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry Paraffin (IHC-P). WB~~1:1000 IHC-P~~1:50~100. Researchers should empirically determine the suitability of the TDGF1 tdgf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRIPTO (TDGF1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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