Western Blot (WB)
(COX7A2L Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)
Rabbit anti-Human, mouse COX7A2L Polyclonal Antibody | anti-COX7A2L antibody
COX7A2L Antibody (Center)
IHC-P~~1:10~50
Western Blot (WB)
(COX7A2L Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)
Western Blot (WB)
(COX7A2L Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)
Western Blot (WB)
(COX7A2L Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)
Western Blot (WB)
(COX7A2L Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)
Immunohistochemistry (IHC)
(COX7A2L Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COX7A2L Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(COX7A2L Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COX7A2L Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. This component is a
heteromeric complex consisting of 3 catalytic subunits encoded by
mitochondrial genes and multiple structural subunits encoded by
nuclear genes. The mitochondrially-encoded subunits function in
electron transfer, and the nuclear-encoded subunits may function in
the regulation and assembly of the complex. This nuclear gene
encodes a protein similar to polypeptides 1 and 2 of subunit VIIa
in the C-terminal region, and also highly similar to the mouse
Sig81 protein sequence. This gene is expressed in all tissues, and
upregulated in a breast cancer cell line after estrogen treatment.
It is possible that this gene represents a regulatory subunit of
COX and mediates the higher level of energy production in target
cells by estrogen.
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
Schmidt, T.R., et al. J. Mol. Evol. 57(2):222-228(2003)
Lee, N., et al. Am. J. Hum. Genet. 68(2):397-409(2001)
NCBI and Uniprot Product Information
NCBI Description
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008]
Uniprot Description
COX7A2L: May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen. Belongs to the cytochrome c oxidase VIIa family.
Protein type: Oxidoreductase; Energy Metabolism - oxidative phosphorylation; Mitochondrial
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain
Molecular Function: cytochrome-c oxidase activity
Biological Process: cellular metabolic process; transmembrane transport
Research Articles on COX7A2L
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Product Notes
The COX7A2L cox7a2l (Catalog #AAA9211832) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 37-65. The COX7A2L Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's COX7A2L can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000 IHC-P~~1:10~50. Researchers should empirically determine the suitability of the COX7A2L cox7a2l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COX7A2L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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