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Western Blot (WB) (COX7A2L Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)

Rabbit anti-Human, Mouse COX7A2L Polyclonal Antibody | anti-COX7A2L antibody

COX7A2L, ID (COX7A2L, COX7AR, COX7RP, Cytochrome c oxidase subunit 7A-related protein, mitochondrial, COX7a-related protein, Cytochrome c oxidase subunit VIIa-related protein, EB1) (FITC)

Gene Names
COX7A2L; EB1; SIG81; COX7AR; COX7RP
Reactivity
Human, Mouse
Applications
Immunohistochemistry, Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
COX7A2L; Polyclonal Antibody; ID (COX7A2L; COX7AR; COX7RP; Cytochrome c oxidase subunit 7A-related protein; mitochondrial; COX7a-related protein; Cytochrome c oxidase subunit VIIa-related protein; EB1) (FITC); EB1; anti-COX7A2L antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Applicable Applications for anti-COX7A2L antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.
Immunogen
COX7A2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the Central region of human COX7A2L.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(COX7A2L Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)

Western Blot (WB) (COX7A2L Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)

Western Blot (WB)

(COX7A2L Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)

Western Blot (WB) (COX7A2L Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the COX7A2L antibody detected the COX7A2L protein (arrow).)

Immunohistochemistry (IHC)

(COX7A2L Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COX7A2L Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (COX7A2L Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COX7A2L Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Related Product Information for anti-COX7A2L antibody
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.
Product Categories/Family for anti-COX7A2L antibody
References
Fornuskova, D., et al. Biochem. J. 428(3):363-374(2010). Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009): Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008). Schmidt, T.R., et al. J. Mol. Evol. 57(2):222-228(2003). Lee, N., et al. Am. J. Hum. Genet. 68(2):397-409(2001).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
12,615 Da
NCBI Official Full Name
cytochrome c oxidase subunit 7A-related protein, mitochondrial
NCBI Official Synonym Full Names
cytochrome c oxidase subunit VIIa polypeptide 2 like
NCBI Official Symbol
COX7A2L
NCBI Official Synonym Symbols
EB1; SIG81; COX7AR; COX7RP
NCBI Protein Information
cytochrome c oxidase subunit 7A-related protein, mitochondrial; COX7a-related protein; estrogen receptor binding CpG island; cytochrome c oxidase subunit VII-related protein; cytochrome c oxidase subunit VIIa-related protein
UniProt Protein Name
Cytochrome c oxidase subunit 7A-related protein, mitochondrial
UniProt Gene Name
COX7A2L
UniProt Synonym Gene Names
COX7AR; COX7RP
UniProt Entry Name
COX7R_HUMAN

NCBI Description

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen.

Subcellular location: Mitochondrion inner membrane

By similarity.

Induction: By estrogen.

Sequence similarities: Belongs to the cytochrome c oxidase VIIa family.

Research Articles on COX7A2L

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Product Notes

The COX7A2L cox7a2l (Catalog #AAA6288156) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COX7A2L, ID (COX7A2L, COX7AR, COX7RP, Cytochrome c oxidase subunit 7A-related protein, mitochondrial, COX7a-related protein, Cytochrome c oxidase subunit VIIa-related protein, EB1) (FITC) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's COX7A2L can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), FLISA, Western Blot (WB). IHC: 1:10-50 FLISA: 1:1,000 WB: 1:100-500 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the COX7A2L cox7a2l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COX7A2L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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