Rabbit anti-Mouse COX7A1 Polyclonal Antibody | anti-COX7A1 antibody

COX7A1, ID (COX7A1, COX7AH, Cytochrome c oxidase subunit 7A1, mitochondrial, Cytochrome c oxidase subunit VIIa-heart, Cytochrome c oxidase subunit VIIa-muscle) (FITC)

Cat. Num. AAA6288145

• Gene Names: COX7A1; COX7A; COX7AH; COX7AM
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: COX7A1; Polyclonal Antibody; ID (COX7A1; COX7AH; Cytochrome c oxidase subunit 7A1; mitochondrial; Cytochrome c oxidase subunit VIIa-heart; Cytochrome c oxidase subunit VIIa-muscle) (FITC); Cytochrome c oxidase subunit VIIa-muscle; anti-COX7A1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-COX7A1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: COX7A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the Central region of human COX7A1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(COX7A1 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the COX7A1 antibody detected the COX7A1 protein (arrow).)

Related Product Information for anti-COX7A1 antibody

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.

Product Categories/Family for anti-COX7A1 antibody

Antibodies; Enzymes; Cytochrome

References

Bailey, S.D., et al. Diabetes Care (2010). In press: Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Lazarou, M., et al. FEBS J. 276(22):6701-6713(2009). Ronn, T., et al. Diabetologia 51(7):1159-1168(2008). Grimwood, J., et al. Nature 428(6982):529-535(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 4502987
• NCBI GeneID: 1346
• NCBI Accession #: NP_001855.1
• NCBI GenBank Nucleotide #: NM_001864.3
• UniProt Accession #: P24310
• NCBI Official Full Name: cytochrome c oxidase subunit 7A1, mitochondrial
• NCBI Official Synonym Full Names: cytochrome c oxidase subunit 7A1
• NCBI Official Symbol: COX7A1
• NCBI Official Synonym Symbols: COX7A; COX7AH; COX7AM
• NCBI Protein Information: cytochrome c oxidase subunit 7A1, mitochondrial
• UniProt Protein Name: Cytochrome c oxidase subunit 7A1, mitochondrial
• Protein Family: Cytochrome c oxidase
• UniProt Gene Name: COX7A1
• UniProt Synonym Gene Names: COX7AH; Cytochrome c oxidase subunit VIIa-H; Cytochrome c oxidase subunit VIIa-M
• UniProt Entry Name: CX7A1_HUMAN

NCBI Description

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. [provided by RefSeq, Jul 2008]

Uniprot Description

COX7A1: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIa family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: mitochondrion; integral to membrane; mitochondrial respiratory chain

Molecular Function: cytochrome-c oxidase activity

Biological Process: generation of precursor metabolites and energy