Rabbit anti-Human RCBTB1 Polyclonal Antibody | anti-RCBTB1 antibody

RCBTB1, ID (RCBTB1, CLLD7, E4.5, RCC1 and BTB domain-containing protein 1, Chronic lymphocytic leukemia deletion region gene 7 protein, Regulator of chromosome condensation and BTB domain-containing protein 1) (Biotin)

Cat. Num. AAA6341028

• Gene Names: RCBTB1; GLP; CLLD7; CLLL7; RP11-185C18.1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: RCBTB1; Polyclonal Antibody; ID (RCBTB1; CLLD7; E4.5; RCC1 and BTB domain-containing protein 1; Chronic lymphocytic leukemia deletion region gene 7 protein; Regulator of chromosome condensation and BTB domain-containing protein 1) (Biotin); Regulator of chromosome condensation and BTB domain-containing protein 1; anti-RCBTB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-RCBTB1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: RCBTB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from the Central region of human RCBTB1.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(RCBTB1 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RCBTB1 antibody detected the RCBTB1 protein (arrow).)

Related Product Information for anti-RCBTB1 antibody

This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies.

Product Categories/Family for anti-RCBTB1 antibody

Antibodies; Cancer Markers; Leukemia

References

Genuneit, J., et al. Clin. Exp. Allergy 39(12):1875-1888(2009). Guo, D.F., et al. J. Biol. Chem. 279(20):21109-21120(2004). Dunham, A., et al. Nature 428(6982):522-528(2004). Solomou, E.E., et al. Leuk. Lymphoma 44(9):1579-1585(2003). Mabuchi, H., et al. Cancer Res. 61(7):2870-2877(2001).

NCBI and Uniprot Product Information

• NCBI GI #: 57242759
• NCBI GeneID: 55213
• NCBI Accession #: NP_060661.3
• NCBI GenBank Nucleotide #: NM_018191.3
• UniProt Accession #: Q8NDN9; Q8IY29; Q969U9
• Molecular Weight: 58,252 Da
• NCBI Official Full Name: RCC1 and BTB domain-containing protein 1
• NCBI Official Synonym Full Names: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
• NCBI Official Symbol: RCBTB1
• NCBI Official Synonym Symbols: GLP; CLLD7; CLLL7; RP11-185C18.1
• NCBI Protein Information: RCC1 and BTB domain-containing protein 1; CLL deletion region gene 7 protein; GDP/GTP exchange factor (GEF)-like protein; chronic lymphocytic leukemia deletion region gene 7 protein; regulator of chromosome condensation and BTB domain-containing protein 1
• UniProt Protein Name: RCC1 and BTB domain-containing protein 1
• Protein Family: RCC1 and BTB domain-containing protein
• UniProt Gene Name: RCBTB1
• UniProt Synonym Gene Names: CLLD7; E4.5; CLL deletion region gene 7 protein
• UniProt Entry Name: RCBT1_HUMAN

NCBI Description

This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008]

Uniprot Description

RCBTB1: May be involved in cell cycle regulation by chromatin remodeling. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation; Cell cycle regulation

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: cytoplasm; nucleus

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification; cell cycle

Disease: Alcohol Dependence