Mouse anti-Human COQ3 Polyclonal Antibody | anti-COQ3 antibody

COQ3 (Dihydroxyhexaprenylbenzoate Methyltransferase, 3,4-dihydroxy-5-hexaprenylbenzoate Methyltransferase, Hexaprenyldihydroxybenzoate Methyltransferase, Mitochondrial, DHHB Methyltransferasem, DHHB-MTase, DHHB-MT, COQ3, UG0215E05)

Cat. Num. AAA6003956

• Gene Names: COQ3; DHHBMT; bA9819.1; DHHBMTASE; UG0215E05
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: COQ3; Polyclonal Antibody; COQ3 (Dihydroxyhexaprenylbenzoate Methyltransferase; 3; 4-dihydroxy-5-hexaprenylbenzoate Methyltransferase; Hexaprenyldihydroxybenzoate Methyltransferase; Mitochondrial; DHHB Methyltransferasem; DHHB-MTase; DHHB-MT; UG0215E05); Anti -COQ3 (Dihydroxyhexaprenylbenzoate Methyltransferase; anti-COQ3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human COQ3.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MWSGRKLGSSGGWFLRVLGPGGCNTKAARPLISSAVYVKNQLSGTLQIKPGVFNEYRTIWFKSYRTIFSCLNRIKSFRYPWARLYSTSQTTVDSGEVKTFLALAHKWWDEQGVYAPLHSMNDLRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQCHKSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHVIDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQIAGIVPKGTHTWEKFVSPETLESILESNGLSVQTVVGMLYNPFSGYWHWSENTSLNYAAHAVKSRVQEHPASAEFVLKGETEELQANACTNPAVHEKLKK

• Applicable Applications for anti-COQ3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml
• Immunogen: Full length human COQ3, aa1-369 (AAH63463.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(COQ3 polyclonal antibody. Western Blot analysis of COQ3 expression in HeLa.)

Western Blot (WB)

(Western Blot analysis of COQ3 expression in transfected 293T cell line by COQ3 polyclonal antibody. Lane 1: COQ3 transfected lysate (40.59kD). Lane 2: Non-transfected lysate.)

Immunohistochemistry (IHC)

(Immunoperoxidase of purified antibody to COQ3 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3ug/ml].)

Related Product Information for anti-COQ3 antibody

Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. COQ3 is an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.

Product Categories/Family for anti-COQ3 antibody

Antibodies; Abs to Enzymes; Methyltransferase

NCBI and Uniprot Product Information

• NCBI GI #: 40225657
• NCBI GeneID: 51805
• UniProt Accession #: Q9NZJ6; Q5T061; Q6P4F0; Q8IXG6; Q96BG1; Q9H0N1; B3KPX0
• Molecular Weight: 41,054 Da
• NCBI Official Full Name: COQ3 protein
• NCBI Official Synonym Full Names: coenzyme Q3 methyltransferase
• NCBI Official Symbol: COQ3
• NCBI Official Synonym Symbols: DHHBMT; bA9819.1; DHHBMTASE; UG0215E05
• NCBI Protein Information: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; DHHB-MT; DHHB-MTase; DHHB methyltransferase; methyltransferase COQ3; 2-polyprenyl-6-hydroxyphenyl methylase; coenzyme Q3 homolog, methyltransferase; 3-demethylubiquinone-10 3-methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; polyprenyldihydroxybenzoate methyltransferase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
• UniProt Protein Name: Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
• UniProt Gene Name: COQ3
• UniProt Synonym Gene Names: DHHB methyltransferase; DHHB-MT; DHHB-MTase
• UniProt Entry Name: COQ3_HUMAN

NCBI Description

Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

Uniprot Description

COQ3: Belongs to the methyltransferase superfamily. UbiG/COQ3 family

Protein type: Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; EC 2.1.1.114; Mitochondrial; EC 2.1.1.64; EC 2.1.1.222; Methyltransferase

Chromosomal Location of Human Ortholog: 6q16.2

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: 3-demethylubiquinone-9 3-O-methyltransferase activity; hexaprenyldihydroxybenzoate methyltransferase activity; O-methyltransferase activity; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

Biological Process: methylation; ubiquinone biosynthetic process; glycerol metabolic process