Rabbit Cofilin 1 Polyclonal Antibody | anti-COFILIN antibody
Cofilin 1, phosphorylated (Tyr139) (Cofilin-1, 18kD Phosphoprotein, p18, Cofilin, Non-muscle Isoform, CFL1, CFL)
Gene Names
COFILIN; CFL1
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
Cofilin 1; Polyclonal Antibody; phosphorylated (Tyr139) (Cofilin-1; 18kD Phosphoprotein; p18; Cofilin; Non-muscle Isoform; CFL1; CFL); Anti -Cofilin 1; anti-COFILIN antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human Cofilin1 when phosphorylated at tyrosine 139. Species Cross-Reactivity: mouse, rat.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Applicable Applications for anti-COFILIN antibody
Immunohistochemistry (IHC)
Application Notes
Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry:1:50-100
Dilution: Immunohistochemistry:1:50-100
Immunogen
Synthetic phosphopeptide corresponding to human cofilin1 around the phosphorylation site of tyrosine 139 (N-C-YP-E-E).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-COFILIN antibody
Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner.
Product Categories/Family for anti-COFILIN antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,519 Da
NCBI Official Full Name
cofilin-1
NCBI Official Symbol
COFILIN
NCBI Official Synonym Symbols
CFL1
NCBI Protein Information
cofilin-1; cofilin, non-muscle isoform
UniProt Protein Name
Cofilin-1
UniProt Gene Name
CFL1
UniProt Entry Name
COF1_PIG
Uniprot Description
Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Cytoskeletal
Cellular Component: nuclear matrix; cytoplasm; actin cytoskeleton
Molecular Function: actin binding
Biological Process: actin filament depolymerization; regulation of cell morphogenesis; cytoskeleton organization and biogenesis
Research Articles on COFILIN
Similar Products
Product Notes
The COFILIN cfl1 (Catalog #AAA624278) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cofilin 1, phosphorylated (Tyr139) (Cofilin-1, 18kD Phosphoprotein, p18, Cofilin, Non-muscle Isoform, CFL1, CFL) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cofilin 1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Suitable for use in Immunohistochemistry. Dilution: Immunohistochemistry:1:50-100. Researchers should empirically determine the suitability of the COFILIN cfl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cofilin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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