Rabbit anti-Human ABCB6 Polyclonal Antibody | anti-ABCB6 antibody

Anti-ABCB6 antibody

Cat. Num. AAA175249

• Gene Names: ABCB6; ABC; LAN; PRP; DUH3; umat; ABC14; MTABC3; MCOPCB7
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry
• Purity: Immunogen affinity purified.
• Synonyms: ABCB6; Polyclonal Antibody; Anti-ABCB6 antibody; ATP-binding cassette sub-family B member 6; mitochondrial; ATP-binding cassette; sub-family B(MDR/TAP); member 6; ABC antibody; ABC transporter umat antibody; ABC14 antibody; Abcb6 antibody; ABCB6_HUMAN antibody; ATP binding cassette sub family B member 6; mitochondrial precursor antibody; ATP binding cassette; sub family B(MDR/TAP); member 6 antibody; ATP-binding cassette sub-family B member 6 antibody; Mitochondrial ABC transporter 3 antibody; mitochondrial antibody; Mt ABC transporter 3 antibody; Mt-ABC transporter 3 antibody; MTABC3 antibody; P glycoprotein related protein antibody; P-glycoprotein-related protein antibody; PRP antibody; Ubiquitously expressed mammalian ABC half transporter antibody; Ubiquitously-expressed mammalian ABC half transporter antibody; UMAT antibody; anti-ABCB6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 842

• Applicable Applications for anti-ABCB6 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB6 (818-842aa YADMWQLQQGQEETSEDTKPQTMER).
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-ABCB6 antibody, MBS175249, Western blottingAll lanes: Anti ABCB6 (MBS175249) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: A549 Whole Cell Lysate at 40ugPredicted bind size: 94KDObserved bind size: 94KD)

Immunohistochemistry (IHC)

(Anti-ABCB6 antibody, MBS175249, IHC(P)IHC(P): Human Mammary Cancer Tissue )

Related Product Information for anti-ABCB6 antibody

Description: Rabbit IgG polyclonal antibody for ATP-binding cassette sub-family B member 6, mitochondrial(ABCB6) detection. Tested with WB, IHC-P, ICC in Human.
Background: ABCB6, ATP-binding cassette sub-family B member 6, mitochondrialis a protein that in humans is encoded by the ABCB6 gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette(ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies(ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.

NCBI and Uniprot Product Information

• NCBI GI #: 13123949
• NCBI GeneID: 10058
• UniProt Accession #: Q9NP58; O75542; Q49A66; Q59GQ5; Q6ZME6; Q96ME8; Q9HAQ6; Q9HAQ7
• Molecular Weight: 88,600 Da
• NCBI Official Full Name: ATP-binding cassette sub-family B member 6, mitochondrial
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
• NCBI Official Symbol: ABCB6
• NCBI Official Synonym Symbols: ABC; LAN; PRP; DUH3; umat; ABC14; MTABC3; MCOPCB7
• NCBI Protein Information: ATP-binding cassette sub-family B member 6, mitochondrial; mt-ABC transporter 3; P-glycoprotein-related protein; mitochondrial ABC transporter 3; ATP-binding cassette half-transporter; ubiquitously-expressed mammalian ABC half transporter
• UniProt Protein Name: ATP-binding cassette sub-family B member 6, mitochondrial
• Protein Family: ABC transporter B family
• UniProt Gene Name: ABCB6
• UniProt Synonym Gene Names: MTABC3; PRP; UMAT; Mt-ABC transporter 3
• UniProt Entry Name: ABCB6_HUMAN

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCB6: Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. Defects in ABCB6 are the cause of microphthalmia, isolated, with coloboma, type 7 (MCOPCB7). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Hydrolase; Mitochondrial; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q36

Cellular Component: mitochondrial envelope; Golgi apparatus; mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; plasma membrane; ATP-binding cassette (ABC) transporter complex; endosome; integral to mitochondrial outer membrane

Molecular Function: efflux transmembrane transporter activity; heme-transporting ATPase activity; heme transporter activity; heme binding; ATP binding

Biological Process: skin development; heme transport; cellular iron ion homeostasis; transport; brain development; porphyrin biosynthetic process; transmembrane transport

Disease: Dyschromatosis Universalis Hereditaria 3; Blood Group, Langereis System; Microphthalmia, Isolated, With Coloboma 7