Western Blot (WB)
(Western Blot: Sample: Lane1: Rat Blood Cells; Lane2: Human Platelet Cells; Lane3: Rat Serum.)
Rabbit anti-Rat Coagulation Factor II (F2) Polyclonal Antibody | anti-F2 antibody
Polyclonal Antibody to Coagulation Factor II (F2)
MGHHHHHHSG SEF- TFGLGEA DCGLRPLFEK KSLTDKTEKE LLDSYIDGRI VEGWDAEKGI APWQVMLFRK SPQELLCGAS LISDRWVLTA AHCILYPPWD KNFTENDLLV RIGKHSRTRY ERNVEKISML EKIYIHPRYN WRENLDRDIA LLKLKKPVPF SDYIHPVCLP DKQTVTSLLQ AGYKGRVTGW GNLRETWTTN INEIQPSVLQ VVNLPIVERP VCKASTRIRI TDNMFCAGFK VNDTKRGDAC EGDSGGPFVM KSPYNHRWYQ MGIVSWGEGC DRNGKYGFYT
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Lane1: Rat Blood Cells; Lane2: Human Platelet Cells; Lane3: Rat Serum.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Rat Blood Cells; Lane2: Human Platelet Cells; Lane3: Rat Serum.)
Western Blot (WB)
(Western Blot: Sample: Recombinant F2, Rat.)
Western Blot (WB)
(Western Blot: Sample: Recombinant F2, Rat.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Uterus Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Uterus Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Ovary Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Ovary Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Intestine Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Intestine Tissue)
NCBI and Uniprot Product Information
NCBI Description
catalyzes the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptides A and B; involved in blood coagulation and wound repair [RGD, Feb 2006]
Uniprot Description
prothrombin: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Defects in F2 are the cause of factor II deficiency (FA2D). It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1). It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2). A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Belongs to the peptidase S1 family.
Protein type: Apoptosis; EC 3.4.21.5; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q24
Cellular Component: external side of plasma membrane; extracellular matrix; extracellular space
Molecular Function: calcium ion binding; heparin binding; lipopolysaccharide binding; peptidase activity; receptor binding; serine-type endopeptidase activity
Biological Process: acute-phase response; blood coagulation; cell surface receptor signaling pathway; cytolysis by host of symbiont cells; fibrinolysis; negative regulation of astrocyte differentiation; negative regulation of proteolysis; platelet activation; positive regulation of blood coagulation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; proteolysis; regulation of cell shape; regulation of cytosolic calcium ion concentration; regulation of gene expression; response to inactivity; response to wounding
Research Articles on F2
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Product Notes
The F2 f2 (Catalog #AAA2013502) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Coagulation Factor II (F2) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Coagulation Factor II (F2) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the F2 f2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- TFGLGEA DCGLRPLFEK KSLTDKTEKE LLDSYIDGRI VEGWDAEKGI APWQVMLFRK SPQELLCGAS LISDRWVLTA AHCILYPPWD KNFTENDLLV RIGKHSRTRY ERNVEKISML EKIYIHPRYN WRENLDRDIA LLKLKKPVPF SDYIHPVCLP DKQTVTSLLQ AGYKGRVTGW GNLRETWTTN INEIQPSVLQ VVNLPIVERP VCKASTRIRI TDNMFCAGFK VNDTKRGDAC EGDSGGPFVM KSPYNHRWYQ MGIVSWGEGC DRNGKYGFYT. It is sometimes possible for the material contained within the vial of "Coagulation Factor II (F2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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