Rabbit BCCIP Polyclonal Antibody | anti-BCCIP antibody

BCCIP Polyclonal Antibody

Cat. Num. AAA2554259

• Gene Names: BCCIP; TOK1; TOK-1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: BCCIP; Polyclonal Antibody; BCCIP Polyclonal Antibody; bccip; BCCIPalpha; BCCIPbeta; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; BRCA2 and Cip1/p21 interacting protein; Cdk inhibitor p21 binding protein; P21 and CDK associated protein 1; P21- and CDK-associated protein 1; Protein TOK-1; Protein TOK1; TOK 1; TOK 1alpha; TOK 1beta; TOK1; anti-BCCIP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 322

• Applicable Applications for anti-BCCIP antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:100-1:200
• Immunogen: Recombinant protein of human BCCIP
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using BCCIP antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric cancer using BCCIP antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer using BCCIP antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human stomach using BCCIP antibody.)

Related Product Information for anti-BCCIP antibody

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Product Categories/Family for anti-BCCIP antibody

Cell Biology; Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 7706581
• NCBI GeneID: 56647
• NCBI Accession #: NP_057651.1
• NCBI GenBank Nucleotide #: NM_016567.3
• UniProt Accession #: Q9P287; Q8ND15; Q96GC4; Q9P288; B3KP45
• Molecular Weight: Calculated: 33kDa; 35kDa; 36kDa; Observed: 50kDa
• NCBI Official Full Name: BRCA2 and CDKN1A-interacting protein isoform BCCIPalpha
• NCBI Official Synonym Full Names: BRCA2 and CDKN1A interacting protein
• NCBI Official Symbol: BCCIP
• NCBI Official Synonym Symbols: TOK1; TOK-1
• NCBI Protein Information: BRCA2 and CDKN1A-interacting protein
• UniProt Protein Name: BRCA2 and CDKN1A-interacting protein
• Protein Family: BRCA2 and CDKN1A-interacting protein
• UniProt Gene Name: BCCIP
• UniProt Synonym Gene Names: TOK1

NCBI Description

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).