Western Blot (WB)
(CLSTN1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CLSTN1 antibody detected the CLSTN1 protein (arrow).)
Rabbit anti-Human CLSTN1 Polyclonal Antibody | anti-CLSTN1 antibody
CLSTN1, NT (CLSTN1, CS1, KIAA0911, Calsyntenin-1, Alcadein-alpha, Alzheimer-related cadherin-like protein, Non-classical cadherin XB31alpha, Soluble Alc-alpha, CTF1-alpha, C-terminal fragment 1-alpha)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(CLSTN1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CLSTN1 antibody detected the CLSTN1 protein (arrow).)
Western Blot (WB)
(CLSTN1 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CLSTN1 antibody detected the CLSTN1 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Uniprot Description
CLSTN1: Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: Golgi membrane; postsynaptic membrane; endoplasmic reticulum membrane; cell projection; integral to membrane; nucleus; cell junction
Molecular Function: protein binding; X11-like protein binding; kinesin binding; beta-amyloid binding; calcium ion binding
Biological Process: cell adhesion; homophilic cell adhesion
Research Articles on CLSTN1
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Product Notes
The CLSTN1 clstn1 (Catalog #AAA6008480) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CLSTN1, NT (CLSTN1, CS1, KIAA0911, Calsyntenin-1, Alcadein-alpha, Alzheimer-related cadherin-like protein, Non-classical cadherin XB31alpha, Soluble Alc-alpha, CTF1-alpha, C-terminal fragment 1-alpha) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CLSTN1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the CLSTN1 clstn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLSTN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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