Rabbit CHEMR23 / CMKLR1 Polyclonal Antibody | anti-CHEMR23 antibody

Rabbit Polyclonal to Human CHEMR23 / CMKLR1

Cat. Num. AAA243088

• Gene Names: CMKLR1; DEZ; RVER1; ChemR23; CHEMERINR
• Reactivity: Gibbon, Human
• Applications: Immunohistochemistry, Immunocytochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CHEMR23 / CMKLR1; Polyclonal Antibody; Rabbit Polyclonal to Human CHEMR23 / CMKLR1; Anti-CHEMR23 / CMKLR1 Antibody (N-Terminus) IHC-plus; CMKLR1; Chemokine receptor-like 1; DEZ; CHEMERINR; Resolvin E1 receptor; RVER1; Chemokine-like receptor 1; ChemR23; G-protein coupled receptor DEZ; Human CHEMR23; anti-CHEMR23 antibody

• Host: Rabbit
• Reactivity: Gibbon, Human
• Clonality: Polyclonal
• Specificity: Human CMKLR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 371

• Applicable Applications for anti-CHEMR23 antibody: Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC)
• Application Notes: ICC, IHC-P (7 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 19 amino acid peptide from N-terminal extracellular domain of human CMKLR1. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Marmoset (84%).
• Immunogen Type: Synthetic peptide
• Immunogen: CHEMR23 / CMKLR1 antibody was raised against synthetic 19 amino acid peptide from N-terminal extracellular domain of human CMKLR1. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Marmoset (84%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CMKLR1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-CHEMR23 antibody

Chemokine-Like Receptor 1 (CMKLR1) is an chemoattractant receptor. CMKLR1 is thought to act primarily in bone development where it is differentially regulated in osseous and cartilaginous tissue. It also acts as a coreceptor for immunodeficiency viruses. CMKLR1 has two variants that are produced by alternative splicing.

Product Categories/Family for anti-CHEMR23 antibody

Family: GPCR; Subfamily: Chemoattractant

NCBI and Uniprot Product Information

• NCBI GI #: 4758014
• NCBI GeneID: 1240
• NCBI Accession #: NP_004063.1
• NCBI GenBank Nucleotide #: NM_004072.2
• UniProt Accession #: Q99788; O75748; Q3KP37; Q5U0H0; Q99789; A8K6Y5
• Molecular Weight: 42,035 Da
• NCBI Official Full Name: chemokine-like receptor 1 isoform b
• NCBI Official Synonym Full Names: chemokine-like receptor 1
• NCBI Official Symbol: CMKLR1
• NCBI Official Synonym Symbols: DEZ; RVER1; ChemR23; CHEMERINR
• NCBI Protein Information: chemokine-like receptor 1; chemerin receptor; resolvin E1 receptor; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez
• UniProt Protein Name: Chemokine-like receptor 1
• UniProt Gene Name: CMKLR1
• UniProt Synonym Gene Names: CHEMR23; DEZ
• UniProt Entry Name: CML1_HUMAN

Uniprot Description

CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; chemokine receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; regulation of calcium-mediated signaling; positive regulation of fat cell differentiation; immune response; chemotaxis; skeletal development