Rabbit anti-Human, Mouse Cerebellin Precursor Polyclonal Antibody | anti-CBLN1 antibody

Cerebellin Precursor (Cbln1, Precerebellin)

Cat. Num. AAA616593

• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Cerebellin Precursor; Polyclonal Antibody; Cerebellin Precursor (Cbln1; Precerebellin); Anti -Cerebellin Precursor (Cbln1; anti-CBLN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Precerebellin. Species Crossreactivity: mouse
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

• Applicable Applications for anti-CBLN1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 2-4ug'ml; Immunohistochemistry: 2ug/ml
• Immunogen: Synthetic peptide consisting of 15aa from the middle of human precerebellin (Genbank accession No. P23435).
• Positive Control: Mouse cerebellum cell lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of precerebellin in mouse cerebellum lysate with C27490-50 at (A) 2ug/ml and (B) 4ug/ml.)

Related Product Information for anti-CBLN1 antibody

Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q (1). Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway (2); and indirectly enhances

Product Categories/Family for anti-CBLN1 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 4757922
• NCBI GeneID: 869
• NCBI Accession #: NP_004343.1
• NCBI GenBank Nucleotide #: NM_004352.3
• UniProt Accession #: P23435; P02682; Q52M09; B2RAN9
• Molecular Weight: 21,097 Da
• NCBI Official Full Name: cerebellin-1
• NCBI Official Synonym Full Names: cerebellin 1 precursor
• NCBI Official Symbol: CBLN1
• NCBI Protein Information: cerebellin-1; precerebellin; OTTHUMP00000164195
• UniProt Protein Name: Cerebellin-1
• Protein Family: Cerebellin
• UniProt Gene Name: CBLN1
• UniProt Entry Name: CBLN1_HUMAN

NCBI Description

This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq]

Uniprot Description

CBLN1: Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: postsynaptic membrane; extracellular region; cell junction

Molecular Function: protein homodimerization activity

Biological Process: heterophilic cell adhesion; nervous system development; synaptic transmission; positive regulation of synaptogenesis; protein secretion; cerebellar granule cell differentiation