Rabbit anti-Human CBLN1 Polyclonal Antibody | anti-CBLN1 antibody

CBLN1 Antibody

Cat. Num. AAA9412698

• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CBLN1; Polyclonal Antibody; CBLN1 Antibody; Cerebellin-1; Precerebellin; anti-CBLN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total CBLN1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 193

• Applicable Applications for anti-CBLN1 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human CBLN1.
• Target Name: CBLN1
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from HUVEC cells, using CBLN1 antibody.)

Related Product Information for anti-CBLN1 antibody

Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion By similarity.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release By similarity.Urade Y., Proc. Natl. Acad. Sci. U.S.A. 88:1069-1073(1991).Ota T., Nat. Genet. 36:40-45(2004).Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

Product Categories/Family for anti-CBLN1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4757922
• NCBI GeneID: 869
• NCBI Accession #: NP_004343.1
• NCBI GenBank Nucleotide #: NM_004352.3
• UniProt Accession #: P23435; P02682; Q52M09; B2RAN9
• Molecular Weight: 21,097 Da
• NCBI Official Full Name: cerebellin-1
• NCBI Official Synonym Full Names: cerebellin 1 precursor
• NCBI Official Symbol: CBLN1
• NCBI Protein Information: cerebellin-1
• UniProt Protein Name: Cerebellin-1
• Protein Family: Cerebellin
• UniProt Gene Name: CBLN1
• UniProt Synonym Gene Names: CER
• UniProt Entry Name: CBLN1_HUMAN

NCBI Description

This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]

Uniprot Description

CBLN1: Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: postsynaptic membrane; extracellular region; cell junction

Molecular Function: protein homodimerization activity

Biological Process: heterophilic cell adhesion; synaptic transmission; positive regulation of synaptogenesis; nervous system development; protein secretion; cerebellar granule cell differentiation