Rabbit anti-Human CELF4 Polyclonal Antibody | anti-CELF4 antibody

CELF4 (BRUNOL4, CUGBP Elav-like Family Member 4, CELF-4, Bruno-like Protein 4, CUG-BP- and ETR-3-like Factor 4, RNA-binding Protein BRUNOL-4)

Cat. Num. AAA648238

• Gene Names: CELF4; BRUNOL4; BRUNOL-4
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CELF4; Polyclonal Antibody; CELF4 (BRUNOL4; CUGBP Elav-like Family Member 4; CELF-4; Bruno-like Protein 4; CUG-BP- and ETR-3-like Factor 4; RNA-binding Protein BRUNOL-4); Anti -CELF4 (BRUNOL4; anti-CELF4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BRUNOL4.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSHRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAAAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPFGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY

• Applicable Applications for anti-CELF4 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human BRUNOL4, aa1-484 (AAH01946.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of BRUNOL4 expression in transfected 293T cell line by BRUNOL4 polyclonal antibody. Lane 1: BRUNOL4 transfected lysate (51.8kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-CELF4 antibody

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Product Categories/Family for anti-CELF4 antibody

Antibodies; Abs to RNA Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 187761303
• NCBI GeneID: 56853
• NCBI Accession #: NP_001020260.1
• NCBI GenBank Nucleotide #: NM_001025089.1
• UniProt Accession #: Q9BZC1; Q59EN7; Q86XB9; Q8N2M6; Q9BQ96; Q9NR84; Q9NR85
• Molecular Weight: 51,966 Da
• NCBI Official Full Name: CUGBP Elav-like family member 4 isoform 4
• NCBI Official Synonym Full Names: CUGBP, Elav-like family member 4
• NCBI Official Symbol: CELF4
• NCBI Official Synonym Symbols: BRUNOL4; BRUNOL-4
• NCBI Protein Information: CUGBP Elav-like family member 4; CELF-4; bruno-like protein 4; RNA-binding protein BRUNOL4; RNA-binding protein BRUNOL-4; LYST-interacting protein LIP9; CUG-BP and ETR-3 like factor 4; CUG-BP- and ETR-3-like factor 4; bruno-like 4, RNA binding protein; Bruno -like 4, RNA binding protein
• UniProt Protein Name: CUGBP Elav-like family member 4
• Protein Family: CUGBP Elav-like family
• UniProt Gene Name: CELF4
• UniProt Synonym Gene Names: BRUNOL4; CELF-4
• UniProt Entry Name: CELF4_HUMAN

NCBI Description

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Ref.1 Ref.7 Ref.8 Ref.9 Ref.10

Subcellular location: Nucleus. Cytoplasm Ref.9.

Tissue specificity: Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes. Ref.1 Ref.6 Ref.11

Sequence similarities: Belongs to the CELF/BRUNOL family.Contains 3 RRM (RNA recognition motif) domains.

Sequence caution: The sequence BAD93011.1 differs from that shown. Reason: Erroneous initiation.