Rabbit anti-Human CELF4 Polyclonal Antibody | anti-CELF4 antibody

CELF4 (BRUNOL4, CUGBP Elav-like Family Member 4, CELF-4, Bruno-like Protein 4, CUG-BP-and ETR-3-like Factor 4, RNA-binding Protein BRUNOL-4) (Biotin)

Cat. Num. AAA6371466

• Gene Names: CELF4; CELF-4; BRUNOL4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CELF4; Polyclonal Antibody; CELF4 (BRUNOL4; CUGBP Elav-like Family Member 4; CELF-4; Bruno-like Protein 4; CUG-BP-and ETR-3-like Factor 4; RNA-binding Protein BRUNOL-4) (Biotin); anti-CELF4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BRUNOL4.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 2278

• Applicable Applications for anti-CELF4 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human BRUNOL4, aa1-484 (AAH01946.2).
• Immunogen Sequence: MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSHRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAAAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPFGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of BRUNOL4 expression in transfected 293T cell line by BRUNOL4 polyclonal antibody. Lane 1: BRUNOL4 transfected lysate (51.8kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-CELF4 antibody

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Product Categories/Family for anti-CELF4 antibody

Antibodies; RNA Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 12804984
• NCBI GeneID: 56853
• NCBI Official Full Name: Homo sapiens bruno-like 4, RNA binding protein (Drosophila), mRNA
• NCBI Official Synonym Full Names: CUGBP Elav-like family member 4
• NCBI Official Symbol: CELF4
• NCBI Official Synonym Symbols: CELF-4; BRUNOL4
• NCBI Protein Information: CUGBP Elav-like family member 4
• Protein Family: CUGBP Elav-like family

NCBI Description

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]