Structure
ALDH1A inhibitor 673A, Inhibitor
ALDH1A inhibitor 673A
Purity
>98% (HPLC)
Synonyms
ALDH1A inhibitor 673A; ALDH1Ai 673A; inhibitor
Purity/Purification
>98% (HPLC)
Target
ALDH
Receptor
ALDH
Chemical Name
4-(isoindolin-2-yl)benzaldehyde
SMILES
C1C2=CC=CC=C2CN1C3=CC=C(C=C3)C=O
Molecular Formula
C15H13NO
CAS Number
109437-62-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ALDH1A inhibitor 673A, inhibitor
ALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor with IC50 of 246, 230 and 348nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively; shows no significant activity against ALDH2 (IC50 14 mM) or numerous other ALDH family members; ALDH1Ai 673A preferentially kills CD133+ ovarian cancer stem-like cells (CSCs), induces necroptotic CSC death, mediated, in part, by the induction of mitochondrial uncoupling proteins (UCPs) and reduction in oxidative phosphorylation; ALDH1Ai 673A is highly synergistic with chemotherapy, reducing tumor initiation capacity and increasing tumor eradication in vivo.
Product Categories/Family for ALDH1A inhibitor 673A, inhibitor
References
1. Chefetz I, et al. Cell Rep. 2019 Mar 12; 26 (11):3061-3075.e6.
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Product Notes
The ALDH1A inhibitor 673A (Catalog #AAA3600366) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ALDH1A inhibitor 673A, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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