Rabbit anti-Mouse CEL Polyclonal Antibody | anti-CEL antibody

Anti-CEL Antibody, Rabbit Polyclonal

Cat. Num. AAA8111786

• Gene Names: Cel; BAL; 1810036E18Rik
• Reactivity: Mouse
• Applications: ELISA
• Purity: Protein A
• Synonyms: CEL; Polyclonal Antibody; Anti-CEL Antibody; Rabbit Polyclonal; CEL Antibody; Rabbit PAb; carboxyl ester lipase; Anti-1810036E18Rik Antibody; Anti-BAL Antibody; anti-CEL antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse CEL
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CEL antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Mouse CEL Protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse CEL (rM CEL). Total IgG was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CEL antibody

CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activated carboxylic ester lipase (CEL) is a major triglyceride, cholesterol ester and vitamin ester hydrolytic enzyme contained within pancreatic and lactating mammary gland secretions. Carboxyl ester lipase is a digestive pancreatic enzyme encoded by the CEL gene. Mutations in CEL cause maturity-onset diabetes of the young as well as pancreatic exocrine dysfunction. The enzyme carboxyl ester lipase (CEL), also known as bile salt-dependent or -stimulated lipase (BSDL, BSSL), hydrolyzes dietary fat, cholesteryl esters and fat-soluble vitamins in the duodenum. CEL is mainly expressed in pancreatic acinar cells and lactating mammary glands. The human CEL gene resides on chromosome 9q34.3 and contains a variable number of tandem repeats (VNTR) region that encodes a mucin-like protein tail.

NCBI and Uniprot Product Information

• NCBI GI #: 6753406
• NCBI GeneID: 12613
• NCBI Accession #: NP_034015.1
• NCBI GenBank Nucleotide #: NM_009885.1
• UniProt Accession #: Q64285
• Molecular Weight: 65,813 Da
• NCBI Official Full Name: bile salt-activated lipase
• NCBI Official Synonym Full Names: carboxyl ester lipase
• NCBI Official Symbol: Cel
• NCBI Official Synonym Symbols: BAL; 1810036E18Rik
• NCBI Protein Information: bile salt-activated lipase; BSSL; sterol esterase; cholesterol esterase; bile salt-stimulated lipase; pancreatic lysophospholipase
• UniProt Protein Name: Bile salt-activated lipase
• Protein Family: Cellulase
• UniProt Gene Name: Cel
• UniProt Synonym Gene Names: Lip1; BAL; BSSL
• UniProt Entry Name: CEL_MOUSE

Uniprot Description

CEL: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8); also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Lipid Metabolism - glycerolipid; Lipase; Lipid Metabolism - steroid biosynthesis; Secreted; EC 3.1.1.3; EC 3.1.1.13

Cellular Component: Golgi apparatus; extracellular space; protein complex; rough endoplasmic reticulum; intracellular membrane-bound organelle; cytoplasm; extracellular region; cytosol; lipid raft

Molecular Function: sterol esterase activity; retinyl-palmitate esterase activity; triacylglycerol lipase activity; hydrolase activity; protein complex binding; glycosphingolipid binding; lysophospholipase activity

Biological Process: retinol metabolic process; ceramide catabolic process; lipid metabolic process; pancreatic juice secretion; cholesterol catabolic process; lipid catabolic process