Rabbit anti-Human MAZ Polyclonal Antibody | anti-MAZ antibody

MAZ Antibody (Center)

Cat. Num. AAA9216103

• Gene Names: MAZ; PUR1; ZF87; Pur-1; SAF-1; SAF-2; SAF-3; Zif87; ZNF801
• Reactivity: Human
• Applications: Western Blot
• Synonyms: MAZ; Polyclonal Antibody; MAZ Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); Myc-associated zinc finger protein; MAZI; Pur-1; Purine-binding transcription factor; Serum amyloid A-activating factor-1; SAF-1; Transcription factor Zif87; ZF87; Zinc finger protein 801; ZNF801; anti-MAZ antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This MAZ antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 295-327 amino acids from the Central region of human MAZ.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 493

• Applicable Applications for anti-MAZ antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:1000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-MAZ Antibody (Center) at 1:1000 dilutionLane 1: A549 whole cell lysateLane 2: CCRF-CEM whole cell lysateLane 3: Hela whole cell lysateLane 4: HT-1080 whole cell lysateLane 5: THP-1 whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 49 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-MAZ antibody

May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.

References

Bossone S.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7452-7456(1992). Pyrc J.J.,et al.Biochemistry 31:4102-4110(1992). Tsutsui H.,et al.Biochem. Biophys. Res. Commun. 226:801-809(1996). Parks C.L.,et al.J. Biol. Chem. 271:4417-4430(1996). Song J.,et al.J. Biol. Chem. 273:20603-20614(1998).

NCBI and Uniprot Product Information

• NCBI GI #: 110347459
• NCBI GeneID: 4150
• NCBI Accession #: NP_001036004.1
• NCBI GenBank Nucleotide #: NM_001042539.2
• UniProt Accession #: P56270; Q15703; Q8NFN7; Q99443; A8QJL9; C6G496; G5E927; H3BQD6
• Molecular Weight: 48608
• NCBI Official Full Name: myc-associated zinc finger protein isoform 2
• NCBI Official Synonym Full Names: MYC-associated zinc finger protein (purine-binding transcription factor)
• NCBI Official Symbol: MAZ
• NCBI Official Synonym Symbols: PUR1; ZF87; Pur-1; SAF-1; SAF-2; SAF-3; Zif87; ZNF801
• NCBI Protein Information: myc-associated zinc finger protein
• UniProt Protein Name: Myc-associated zinc finger protein
• Protein Family: Myc-associated zinc finger protein
• UniProt Gene Name: MAZ
• UniProt Synonym Gene Names: ZNF801; MAZI; SAF-1
• UniProt Entry Name: MAZ_HUMAN

NCBI Description

MAZ: a myc-associated zinc finger protein. An inflammation-responsive transcription factor with dual roles in transcription initiation and termination. Binds to two sites within the c-myc promoter. Also binds to multiple G/C-rich sites within the promoter of the SP1 family of transcription factors. Expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.

Protein type: C2H2-type zinc finger protein; RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; chromatin binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; termination of RNA polymerase II transcription

Uniprot Description

MAZ: a myc-associated zinc finger protein. An inflammation-responsive transcription factor with dual roles in transcription initiation and termination. Binds to two sites within the c-myc promoter. Also binds to multiple G/C-rich sites within the promoter of the SP1 family of transcription factors. Expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.

Protein type: C2H2-type zinc finger protein; Transcription factor; RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleus

Molecular Function: chromatin binding; metal ion binding; protein binding

Biological Process: regulation of transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; transcription initiation from RNA polymerase II promoter