Immunohistochemistry (IHC)
(Sample Data: Anti-CDK5 antibody was diluted 1:500 to detect CDK5 in human brain cortex tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.)
CDK5 Polyclonal Antibody | anti-CDK5 antibody
Anti-CDK5
Reactivity
Human, Rat, Mouse
Applications
ELISA, Immunoprecipitation, Western Blot
Purity
Delipidation and defibrination
Synonyms
CDK5; Polyclonal Antibody; Anti-CDK5; anti-CDK5 antibody
Host
Rabbit, Antiserum
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Specificity
Recognizes the 35kDa CDK5 (p31) protein
Purity/Purification
Delipidation and defibrination
Form/Format
0.01% (w/v) Sodium Azide
Applicable Applications for anti-CDK5 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Immunogen
The antibody was produced against synthesized peptide corresponding to the C-Terminus of human CDK5 protein conjugated to KLH.
Preparation and Storage
1 year at -20 degree C from date of shipment
Immunohistochemistry (IHC)
(Sample Data: Anti-CDK5 antibody was diluted 1:500 to detect CDK5 in human brain cortex tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.)
Immunohistochemistry (IHC)
(Sample Data: Anti-CDK5 antibody was diluted 1:500 to detect CDK5 in human brain cortex tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.)
Related Product Information for anti-CDK5 antibody
The neuronal protein kinase, CDK5 is implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis (1), the presynaptic vesicle cycle (2), neurotransmitter receptor trafficking, and dopamine neurotransmission (3). CDK5 is active as a heterodimer with a 25kDa protein. The 25kDa protein is derived proteolytically from a 35kDa brain and neuron-specific precursor protein (4). CDK5 phosphorylates a diverse list of substrates and has been implicated in a wide range of neurological and neuropsychiatric disorders, which include Alzheimer's, Parkinson's, Huntington's, epilepsy, schizophrenia, and drug addiction (5).
Product Categories/Family for anti-CDK5 antibody
References
1. Kansy, J. et al. Identification of tyrosine hydroxylase as a physiological substrate of Cdk5. J. Neurochem. 2004 91, 374-384.
2. Nguyen, C. et al: Cdk5 and the mystery of synaptic vesicle endocytosis. J Cell Biol. 2003 163, 697-699. Bibb, J A. et al. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signaling in neurons. Nature 1999 402, 669-671.
3. Tang, D. et al: Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators. Prog Cell Cycle Res. 1996;2:205-16.
4. Dhavan, R. et al: A decade of CDK5. Nat Rev Mol Cell Biol. 2001 Oct;2(10):749-59.
2. Nguyen, C. et al: Cdk5 and the mystery of synaptic vesicle endocytosis. J Cell Biol. 2003 163, 697-699. Bibb, J A. et al. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signaling in neurons. Nature 1999 402, 669-671.
3. Tang, D. et al: Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators. Prog Cell Cycle Res. 1996;2:205-16.
4. Dhavan, R. et al: A decade of CDK5. Nat Rev Mol Cell Biol. 2001 Oct;2(10):749-59.
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Product Notes
The CDK5 (Catalog #AAA515905) is an Antibody produced from Rabbit, Antiserum and is intended for research purposes only. The product is available for immediate purchase. The Anti-CDK5 reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CDK5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB). Researchers should empirically determine the suitability of the CDK5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDK5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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