Goat CD193 Polyclonal Antibody | anti-CD193 antibody

GOAT ANTI MOUSE CD193 (N-TERMINAL)

Cat. Num. AAA223599

• Gene Names: Ccr3; CKR3; Cmkbr3; CC-CKR3; Cmkbr1l2
• Applications: Immunohistochemistry, Western Blot
• Synonyms: CD193; Polyclonal Antibody; GOAT ANTI MOUSE CD193 (N-TERMINAL); anti-CD193 antibody

• Host: Goat
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 359

• Applicable Applications for anti-CD193 antibody: Immunohistology Paraffin*, Western Blot (WB)
• Application Notes: Immunohistology - Paraffin: Minimum Dilution: 1/125; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.; Western Blotting: Minimum Dilution: 1/500
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin
• Histology Positive Control Tissue: Spleen; Buffer Solution
• Antiserum Preparation: Antiserum to mouse CD193 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
• Target Species: Mouse
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Testing Data #1

(Staining of paraffin embedded mouse spleen with Goat anti Mouse CD193 (MBS223599))

Related Product Information for anti-CD193 antibody

Goat anti Mouse CD193 antibody recognizes an epitope within the N-terminal (NT) region of mouse CD193, otherwise known as C-C chemokine receptor type 3 or CCR3. CD193 is a 359 amino acid ~42 kDa multi pass transmembrane glycoprotein and member of the G-protein coupled receptor 1 family (UniProt: P51678). CD193 is expressed by basophils, eosinophils, microglia, Th2 cells and dendritic cells. CD193 acts as a receptor for eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13) and RANTES (CCL5), the former being a chemoattractant for eosinophils and basophils. CD193 is involved in leukocyte chemotaxis and, along with CD191 (CCR1), is implicated as a regulator of T cell and dendritic cell interaction during the process of antigen presentation. CD193 is implicated as an activator of eosinophils in allergic lung disease, and is a useful TH2 cell marker in monitoring immune responses. Goat anti Mouse CD193 antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells.

NCBI and Uniprot Product Information

• NCBI GI #: 157012009
• NCBI GeneID: 12771
• NCBI Accession #: NP_034044.3
• NCBI GenBank Nucleotide #: NM_009914.4
• UniProt Accession #: P51678; Q8K3M7
• Molecular Weight: 41,783 Da
• NCBI Official Full Name: probable C-C chemokine receptor type 3
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 3
• NCBI Official Symbol: Ccr3
• NCBI Official Synonym Symbols: CKR3; Cmkbr3; CC-CKR3; Cmkbr1l2
• NCBI Protein Information: probable C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CC-CKR-3; CCR-3; MIP-1 alpha RL2; MIP-1 alphaRL2; chemokine (C-C) receptor 1,-like 2; chemokine (C-C) receptor 3; macrophage inflammatory protein 1-alpha receptor-like 2
• UniProt Protein Name: Probable C-C chemokine receptor type 3
• UniProt Gene Name: Ccr3
• UniProt Synonym Gene Names: Cmkbr1l2; Cmkbr3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; MIP-1 alpha RL2
• UniProt Entry Name: CCR3_MOUSE

Uniprot Description

CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, cytokine; Motility/polarity/chemotaxis; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: extracellular space; membrane; plasma membrane; integral to membrane; endosome

Molecular Function: G-protein coupled receptor activity; protein binding; signal transducer activity; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; mast cell chemotaxis; eosinophil chemotaxis; positive regulation of endothelial cell proliferation; inflammatory response; signal transduction; chemotaxis