Rabbit CCR3 Polyclonal Antibody | anti-CCR3 antibody

Anti-CCR3 Antibody (N-Terminus)

Cat. Num. AAA2400589

• Gene Names: CCR3; CKR3; CD193; CMKBR3; CC-CKR-3
• Reactivity: Human; Predicted: Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: CCR3; Polyclonal Antibody; Anti-CCR3 Antibody (N-Terminus); Rabbit Polyclonal to Human CCR3; C-C chemokine receptor type 3; B-chemokine receptor; CD193; CD193 antigen; Chemokine c-c motif receptor 3; C-C chemokine receptor 3; CKR3; CC-CKR-3; CCR-3; CMKBR3; Eosinophil eotaxin receptor; Eotaxin receptor; C-C CKR-3; CC chemokine receptor 3; anti-CCR3 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CCR3. Species cross-reactivity: mouse and rat.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7.2, 0.02% sodium azide.
• Sequence Length: 355

• Applicable Applications for anti-CCR3 antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-P: 5 ug/ml; WB: 1-2 ug/ml
• Immunogen: Synthetic peptide, 14 aa, near the N- terminus of human CCR3 (Genbank accession No. NP_847899).
• Conjugation: Unconjugated
• Epitope: N-Terminus
• Preparation and Storage: May be stored at 4 degree C for short-term only.; Aliquot to avoid repeated freezing and thawing.; Store at -20 degree C.; Aliquots are stable for at least 12 months.

Immunohistochemistry (IHC)

(Anti-CCR3 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-CCR3 antibody

CCR3 is a receptor for C-C type chemokines. It belongs to family 1 of the G protein -coupled receptors. This receptor binds and responds to avariety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells.

Product Categories/Family for anti-CCR3 antibody

GPCR; Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 4502637
• NCBI GeneID: 1232
• NCBI Accession #: NP_001828.1
• NCBI GenBank Nucleotide #: NM_001837.3
• UniProt Accession #: P51677; Q15748; Q2YDB9; Q86WD2; Q8TDP6; Q9ULY8; B3KVQ1; F5GWL6
• Molecular Weight: 43,453 Da
• NCBI Official Full Name: C-C chemokine receptor type 3 isoform 1
• NCBI Official Synonym Full Names: C-C motif chemokine receptor 3
• NCBI Official Symbol: CCR3
• NCBI Official Synonym Symbols: CKR3; CD193; CMKBR3; CC-CKR-3
• NCBI Protein Information: C-C chemokine receptor type 3
• UniProt Protein Name: C-C chemokine receptor type 3
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR3
• UniProt Synonym Gene Names: CMKBR3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3

NCBI Description

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Uniprot Description

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.MiscellaneousOverexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).